Wu MF - Search Results

1

Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis.

Chen Y, Wu MF, Xie MM, Lu Y, Li C, Xie SS, Ma WX, Ji ML, Hou R, Dong ZH, He RB, Zhang MM, Lu H, Gao L, Wen JG, Jin J, Dong XW, Che JX, Meng XM. Chen Y, et al. Among authors: wu mf. Acta Pharmacol Sin. 2024 Aug;45(8):1673-1685. doi: 10.1038/s41401-024-01277-w. Epub 2024 Apr 19. Acta Pharmacol Sin. 2024. PMID: 38641746

2

Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.

Liu XQ, Jin J, Li Z, Jiang L, Dong YH, Cai YT, Wu MF, Wang JN, Ma TT, Wen JG, Liu MM, Li J, Wu YG, Meng XM. Liu XQ, et al. Among authors: wu yg, wu mf. Biochem Pharmacol. 2020 Oct;180:114132. doi: 10.1016/j.bcp.2020.114132. Epub 2020 Jul 3. Biochem Pharmacol. 2020. PMID: 32622666

3

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway.

Li HD, Chen X, Xu JJ, Du XS, Yang Y, Li JJ, Yang XJ, Huang HM, Li XF, Wu MF, Zhang C, Zhang C, Li Z, Wang H, Meng XM, Huang C, Li J. Li HD, et al. Among authors: wu mf. Clin Sci (Lond). 2020 Jul 31;134(14):1935-1956. doi: 10.1042/CS20200031. Clin Sci (Lond). 2020. PMID: 32639005

4

3-B-RUT, a derivative of RUT, protected against alcohol-induced liver injury by attenuating inflammation and oxidative stress.

Xu JJ, Li HD, Wu MF, Zhu L, Du XS, Li JJ, Li Z, Meng XM, Huang C, Li J. Xu JJ, et al. Among authors: wu mf. Int Immunopharmacol. 2021 Jun;95:107471. doi: 10.1016/j.intimp.2021.107471. Epub 2021 Mar 20. Int Immunopharmacol. 2021. PMID: 33756231

5

Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.

Zhang J, Che J, Luo X, Wu M, Kan W, Jin Y, Wang H, Pang A, Li C, Huang W, Zeng S, Zhuang W, Wu Y, Xu Y, Zhou Y, Li J, Dong X. Zhang J, et al. J Med Chem. 2022 Jul 14;65(13):9096-9125. doi: 10.1021/acs.jmedchem.2c00324. Epub 2022 Jun 7. J Med Chem. 2022. PMID: 35671249

6

Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling.

Che J, Li D, Hong W, Wang L, Guo Y, Wu M, Lu J, Tong L, Weng Q, Wang J, Dong X. Che J, et al. Eur J Med Chem. 2022 Dec 5;243:114732. doi: 10.1016/j.ejmech.2022.114732. Epub 2022 Sep 2. Eur J Med Chem. 2022. PMID: 36075147

7

Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer.

Wu Y, Wu M, Zheng X, Yu H, Mao X, Jin Y, Wang Y, Pang A, Zhang J, Zeng S, Xu T, Chen Y, Zhang B, Lin N, Dai H, Wang Y, Yao X, Dong X, Huang W, Che J. Wu Y, et al. Bioorg Chem. 2024 Jan;142:106952. doi: 10.1016/j.bioorg.2023.106952. Epub 2023 Nov 8. Bioorg Chem. 2024. PMID: 37952486

8

Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors.

Guo Y, Shen Z, Zhao W, Lu J, Song Y, Shen L, Lu Y, Wu M, Shi Q, Zhuang W, Qiu Y, Sheng J, Zhou Z, Fang L, Che J, Dong X. Guo Y, et al. Adv Sci (Weinh). 2024 Apr;11(13):e2306309. doi: 10.1002/advs.202306309. Epub 2024 Jan 25. Adv Sci (Weinh). 2024. PMID: 38269648 Free PMC article.

9

Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.

Zeng S, Wu M, Jin Y, Ye Y, Xia H, Chen X, Che J, Wang Z, Wu Y, Dong X, Chen Y, Huang W. Zeng S, et al. Eur J Med Chem. 2024 Mar 5;267:116206. doi: 10.1016/j.ejmech.2024.116206. Epub 2024 Feb 8. Eur J Med Chem. 2024. PMID: 38350360

10

Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML.

Wu M, Wang W, Mao X, Wu Y, Jin Y, Liu T, Lu Y, Dai H, Zeng S, Huang W, Wang Y, Yao X, Che J, Ying M, Dong X. Wu M, et al. Eur J Med Chem. 2024 Sep 5;275:116539. doi: 10.1016/j.ejmech.2024.116539. Epub 2024 May 31. Eur J Med Chem. 2024. PMID: 38878515

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