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Use of HSC-targeted LNP to generate a mouse model of lethal α-thalassemia and treatment via lentiviral gene therapy.
Chappell ME, Breda L, Tricoli L, Guerra A, Jarocha D, Castruccio Castracani C, Papp TE, Tanaka N, Hamilton N, Triebwasser MP, Ghiaccio V, Fedorky MT, Gollomp KL, Bochenek V, Roche AM, Everett JK, Cook EJ, Bushman FD, Teawtrakul N, Glentis S, Kattamis A, Mui BL, Tam YK, Weissman D, Abdulmalik O, Parhiz H, Rivella S. Chappell ME, et al. Among authors: parhiz h. Blood. 2024 Oct 10;144(15):1633-1645. doi: 10.1182/blood.2023023349. Blood. 2024. PMID: 38949981
Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects.
Omo-Lamai S, Wang Y, Patel MN, Essien EO, Shen M, Majumdar A, Espy C, Wu J, Channer B, Tobin M, Murali S, Papp TE, Maheshwari R, Wang L, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Tsourkas A, Muzykantov V, Brodsky I, Shin S, Whitehead KA, Gaskill P, Discher D, Parhiz H, Brenner JS. Omo-Lamai S, et al. Among authors: parhiz h. bioRxiv [Preprint]. 2024 Apr 18:2024.04.16.589801. doi: 10.1101/2024.04.16.589801. bioRxiv. 2024. PMID: 38659905 Free PMC article. Preprint.
Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system.
Parhiz H, Shuvaev VV, Li Q, Papp TE, Akyianu AA, Shi R, Yadegari A, Shahnawaz H, Semple SC, Mui BL, Weissman D, Muzykantov VR, Glassman PM. Parhiz H, et al. Mol Ther Nucleic Acids. 2024 Mar 18;35(2):102175. doi: 10.1016/j.omtn.2024.102175. eCollection 2024 Jun 11. Mol Ther Nucleic Acids. 2024. PMID: 38576454 Free PMC article.
IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.
Tilsed CM, Sadiq BA, Papp TE, Areesawangkit P, Kimura K, Noguera-Ortega E, Scholler J, Cerda N, Aghajanian H, Bot A, Mui B, Tam Y, Weissman D, June CH, Albelda SM, Parhiz H. Tilsed CM, et al. Among authors: parhiz h. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2319856121. doi: 10.1073/pnas.2319856121. Epub 2024 Mar 21. Proc Natl Acad Sci U S A. 2024. PMID: 38513098 Free PMC article.
Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke.
Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Nong J, et al. Among authors: parhiz h. Mol Ther. 2024 May 1;32(5):1344-1358. doi: 10.1016/j.ymthe.2024.03.004. Epub 2024 Mar 7. Mol Ther. 2024. PMID: 38454606
In vivo hematopoietic stem cell modification by mRNA delivery.
Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou ST, Ni H, Mui BL, Tam YK, Weissman D, Rivella S, Parhiz H. Breda L, et al. Among authors: parhiz h. Science. 2023 Jul 28;381(6656):436-443. doi: 10.1126/science.ade6967. Epub 2023 Jul 27. Science. 2023. PMID: 37499029 Free PMC article.
Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke.
Nong J, Glassman PM, Reyes-Esteves S, Descamps HC, Shuvaev VV, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Nong J, et al. Among authors: parhiz h. bioRxiv [Preprint]. 2023 Jun 13:2023.06.12.544645. doi: 10.1101/2023.06.12.544645. bioRxiv. 2023. Update in: Mol Ther. 2024 May 1;32(5):1344-1358. doi: 10.1016/j.ymthe.2024.03.004 PMID: 37398465 Free PMC article. Updated. Preprint.
43 results