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Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput.
Kennedy PH, Alborzian Deh Sheikh A, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer CG, Alarcón S, Newby GA, Myers SA. Kennedy PH, et al. Among authors: gottschalk ra. Nat Methods. 2024 Jun;21(6):1033-1043. doi: 10.1038/s41592-024-02256-z. Epub 2024 Apr 29. Nat Methods. 2024. PMID: 38684783
Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput.
Kennedy PH, Deh Sheikh AA, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer C, Alarcón S, Newby G, Myers SA. Kennedy PH, et al. Among authors: gottschalk ra. bioRxiv [Preprint]. 2023 Nov 14:2023.11.11.566649. doi: 10.1101/2023.11.11.566649. bioRxiv. 2023. Update in: Nat Methods. 2024 Jun;21(6):1033-1043. doi: 10.1038/s41592-024-02256-z PMID: 38014346 Free PMC article. Updated. Preprint.
Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework.
Cheemalavagu N, Shoger KE, Cao YM, Michalides BA, Botta SA, Faeder JR, Gottschalk RA. Cheemalavagu N, et al. Among authors: gottschalk ra. bioRxiv [Preprint]. 2023 May 20:2023.05.19.541151. doi: 10.1101/2023.05.19.541151. bioRxiv. 2023. Update in: Cell Syst. 2024 Jan 17;15(1):37-48.e4. doi: 10.1016/j.cels.2023.12.006 PMID: 37292918 Free PMC article. Updated. Preprint.
Signaling is the pathway to macrophage function.
Gottschalk RA. Gottschalk RA. Trends Immunol. 2023 Jul;44(7):496-498. doi: 10.1016/j.it.2023.04.007. Epub 2023 May 29. Trends Immunol. 2023. PMID: 37258361 Free PMC article.
34 results