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An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
Ziegler CGK, Owings AH, Galeas-Pena M, Kazer SW, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE 3rd, Senitko M, Robinson TO, Diamond G, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC. Ziegler CGK, et al. Among authors: williams hb. Microbiol Spectr. 2024 Jun 4;12(6):e0351623. doi: 10.1128/spectrum.03516-23. Epub 2024 Apr 30. Microbiol Spectr. 2024. PMID: 38687064 Free PMC article.
Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium.
Ziegler CGK, Owings AH, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE 3rd, Senitko M, Robinson TO, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC. Ziegler CGK, et al. Among authors: williams hb. medRxiv [Preprint]. 2022 Oct 26:2022.10.25.22281528. doi: 10.1101/2022.10.25.22281528. medRxiv. 2022. PMID: 36324802 Free PMC article. Preprint.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.
Ziegler CGK, Miao VN, Owings AH, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Christian T, Parker A, Sindel CB, Burger MW, Pride Y, Hasan M, Abraham GE 3rd, Senitko M, Robinson TO, Shalek AK, Glover SC, Horwitz BH, Ordovas-Montanes J. Ziegler CGK, et al. Among authors: williams hb. bioRxiv [Preprint]. 2021 Feb 20:2021.02.20.431155. doi: 10.1101/2021.02.20.431155. bioRxiv. 2021. Update in: Cell. 2021 Sep 2;184(18):4713-4733.e22. doi: 10.1016/j.cell.2021.07.023 PMID: 33619488 Free PMC article. Updated. Preprint.
Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy.
Liu JJ, Sloan ME, Owings AH, Figgins E, Gauthier J, Gharaibeh R, Robinson T, Williams H, Sindel CB, Backus F, Ayyalasomayajula K, Parker A, Senitko M, Abraham GE 3rd, Claggett B, Horwitz BH, Jobin C, Adelman RM, Diamond G, Glover SC. Liu JJ, et al. Am J Gastroenterol. 2021 Aug 1;116(8):1638-1645. doi: 10.14309/ajg.0000000000001311. Am J Gastroenterol. 2021. PMID: 34047305
The gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.
Newsome RC, Gauthier J, Hernandez MC, Abraham GE, Robinson TO, Williams HB, Sloan M, Owings A, Laird H, Christian T, Pride Y, Wilson KJ, Hasan M, Parker A, Senitko M, Glover SC, Gharaibeh RZ, Jobin C. Newsome RC, et al. Among authors: williams hb. Gut Microbes. 2021 Jan-Dec;13(1):1-15. doi: 10.1080/19490976.2021.1926840. Gut Microbes. 2021. PMID: 34100340 Free PMC article.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.
Ziegler CGK, Miao VN, Owings AH, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Christian T, Parker A, Sindel CB, Burger MW, Pride Y, Hasan M, Abraham GE 3rd, Senitko M, Robinson TO, Shalek AK, Glover SC, Horwitz BH, Ordovas-Montanes J. Ziegler CGK, et al. Among authors: williams hb. Cell. 2021 Sep 2;184(18):4713-4733.e22. doi: 10.1016/j.cell.2021.07.023. Epub 2021 Jul 23. Cell. 2021. PMID: 34352228 Free PMC article.
Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.
Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Dhaliwal NS, Everman S, Zafar Y, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y. Tomalka JA, et al. Among authors: williams hb. medRxiv [Preprint]. 2023 Sep 15:2023.09.14.23295549. doi: 10.1101/2023.09.14.23295549. medRxiv. 2023. PMID: 37745424 Free PMC article. Preprint.
Examination of gene expression in saliva samples from COVID-19 patients to study the host defense response against SARS-CoV-2 in the oral cavity.
Diamond G, Figgins EL, Robinson T, Senitko M, Abraham GE, Williams HB, Sloan M, Owings A, Laird H, Pride Y, Wilson KJ, Hasan M, Parker A, Glover SC. Diamond G, et al. Among authors: williams hb. Mol Oral Microbiol. 2021 Apr;36(2):157-158. doi: 10.1111/omi.12327. Epub 2020 Dec 8. Mol Oral Microbiol. 2021. PMID: 34527214 Free PMC article. No abstract available.
101 results