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Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
Pfaffenbach M, Bolduc PN, Xin Z, Gao F, Evans R, Fang T, Chodaparambil JV, Henry KL, Li P, Mathieu S, Metrick C, Vera Rebollar JA, Gu RF, Mccarl CA, Silbereis J, Peterson EA. Pfaffenbach M, et al. Among authors: gu rf. J Med Chem. 2024 May 23;67(10):8383-8395. doi: 10.1021/acs.jmedchem.4c00560. Epub 2024 May 2. J Med Chem. 2024. PMID: 38695469
Proteomic Characterization of the Dynamics of Ischemic Stroke in Mice.
Gu RF, Fang T, Nelson A, Gyoneva S, Gao B, Hedde J, Henry K, Peterson E, Burkly LC, Wei R. Gu RF, et al. J Proteome Res. 2021 Jul 2;20(7):3689-3700. doi: 10.1021/acs.jproteome.1c00259. Epub 2021 Jun 4. J Proteome Res. 2021. PMID: 34085531 Free PMC article.
Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration.
Nagy D, Ennis KA, Wei R, Su SC, Hinckley CA, Gu RF, Gao B, Massol RH, Ehrenfels C, Jandreski L, Thomas AM, Nelson A, Gyoneva S, Hajós M, Burkly LC. Nagy D, et al. Among authors: gu rf. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2001679118. doi: 10.1073/pnas.2001679118. Proc Natl Acad Sci U S A. 2021. PMID: 33526652 Free PMC article.
Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. de Jonge BL, et al. Among authors: gu rf. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. Epub 2013 Sep 16. Antimicrob Agents Chemother. 2013. PMID: 24041904 Free PMC article.
20 results