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Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease.
Williams D, Glasstetter LM, Jong TT, Kapoor A, Zhu S, Zhu Y, Gehrlein A, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Among authors: jagasia r. bioRxiv [Preprint]. 2024 Mar 27:2024.03.22.586364. doi: 10.1101/2024.03.22.586364. bioRxiv. 2024. PMID: 38712038 Free PMC article. Preprint.
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice.
Chang WL, Tegang K, Samuels BA, Saxe M, Wichmann J, David DJ, David IM, Augustin A, Fischer H, Golling S, Lamerz J, Roth D, Graf M, Zoffmann S, Santarelli L, Jagasia R, Hen R. Chang WL, et al. Among authors: jagasia r. bioRxiv [Preprint]. 2024 Feb 4:2024.02.01.578406. doi: 10.1101/2024.02.01.578406. bioRxiv. 2024. PMID: 38352378 Free PMC article. Preprint.
High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.
Williams D, Glasstetter LM, Jong TT, Chen T, Kapoor A, Zhu S, Zhu Y, Calvo R, Gehrlein A, Wong K, Hogan AN, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Among authors: jagasia r. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2406009121. doi: 10.1073/pnas.2406009121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388267 Free PMC article.
Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases.
Moors TE, Morella ML, Bertran-Cobo C, Geut H, Udayar V, Timmermans-Huisman E, Ingrassia AMT, Brevé JJP, Bol JGJM, Bonifati V, Jagasia R, van de Berg WDJ. Moors TE, et al. Among authors: jagasia r. Acta Neuropathol. 2024 Apr 6;147(1):67. doi: 10.1007/s00401-024-02707-z. Acta Neuropathol. 2024. PMID: 38581586 Free PMC article.
DeePhys: A machine learning-assisted platform for electrophysiological phenotyping of human neuronal networks.
Hornauer P, Prack G, Anastasi N, Ronchi S, Kim T, Donner C, Fiscella M, Borgwardt K, Taylor V, Jagasia R, Roqueiro D, Hierlemann A, Schröter M. Hornauer P, et al. Among authors: jagasia r. Stem Cell Reports. 2024 Feb 13;19(2):285-298. doi: 10.1016/j.stemcr.2023.12.008. Epub 2024 Jan 25. Stem Cell Reports. 2024. PMID: 38278155 Free PMC article.
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.
Gehrlein A, Udayar V, Anastasi N, Morella ML, Ruf I, Brugger D, von der Mark S, Thoma R, Rufer A, Heer D, Pfahler N, Jochner A, Niewoehner J, Wolf L, Fueth M, Ebeling M, Villaseñor R, Zhu Y, Deen MC, Shan X, Ehsaei Z, Taylor V, Sidransky E, Vocadlo DJ, Freskgård PO, Jagasia R. Gehrlein A, et al. Among authors: jagasia r. Nat Commun. 2023 Apr 12;14(1):2057. doi: 10.1038/s41467-023-37632-4. Nat Commun. 2023. PMID: 37045813 Free PMC article.
55 results