Deeb TZ - Search Results

1

The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl^- extrusion.

Cho N, Kontou G, Smalley JL, Bope C, Dengler J, Montrose K, Deeb TZ, Brandon NJ, Yamamoto T, Davies PA, Giamas G, Moss SJ. Cho N, et al. Among authors: deeb tz. iScience. 2024 Mar 15;27(4):109512. doi: 10.1016/j.isci.2024.109512. eCollection 2024 Apr 19. iScience. 2024. PMID: 38715938 Free PMC article.

2

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents.

Lee HH, Deeb TZ, Walker JA, Davies PA, Moss SJ. Lee HH, et al. Among authors: deeb tz. Nat Neurosci. 2011 Jun;14(6):736-43. doi: 10.1038/nn.2806. Epub 2011 May 1. Nat Neurosci. 2011. PMID: 21532577 Free PMC article.

3

Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential.

Deeb TZ, Lee HH, Walker JA, Davies PA, Moss SJ. Deeb TZ, et al. Channels (Austin). 2011 Nov-Dec;5(6):475-81. doi: 10.4161/chan.5.6.17952. Epub 2011 Nov 1. Channels (Austin). 2011. PMID: 22082832 Free PMC article.

4

Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states.

Deeb TZ, Nakamura Y, Frost GD, Davies PA, Moss SJ. Deeb TZ, et al. Eur J Neurosci. 2013 Aug;38(3):2453-67. doi: 10.1111/ejn.12241. Epub 2013 Apr 29. Eur J Neurosci. 2013. PMID: 23627375 Free PMC article.

5

KCC2 activity is critical in limiting the onset and severity of status epilepticus.

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. Silayeva L, et al. Among authors: deeb tz. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3523-8. doi: 10.1073/pnas.1415126112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733865 Free PMC article.

6

Compromising KCC2 transporter activity enhances the development of continuous seizure activity.

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ. Kelley MR, et al. Among authors: deeb tz. Neuropharmacology. 2016 Sep;108:103-10. doi: 10.1016/j.neuropharm.2016.04.029. Epub 2016 Apr 21. Neuropharmacology. 2016. PMID: 27108931 Free PMC article.

7

Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.

Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ. Moore YE, et al. Among authors: deeb tz. Trends Neurosci. 2017 Sep;40(9):555-571. doi: 10.1016/j.tins.2017.06.008. Epub 2017 Aug 10. Trends Neurosci. 2017. PMID: 28803659 Review.

8

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy.

Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ. Kelley MR, et al. Among authors: deeb tz. EBioMedicine. 2018 Jun;32:62-71. doi: 10.1016/j.ebiom.2018.05.029. Epub 2018 Jun 5. EBioMedicine. 2018. PMID: 29884458 Free PMC article.

9

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures.

Moore YE, Deeb TZ, Chadchankar H, Brandon NJ, Moss SJ. Moore YE, et al. Among authors: deeb tz. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10166-10171. doi: 10.1073/pnas.1810134115. Epub 2018 Sep 17. Proc Natl Acad Sci U S A. 2018. PMID: 30224498 Free PMC article.

10

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function.

Moore YE, Conway LC, Wobst HJ, Brandon NJ, Deeb TZ, Moss SJ. Moore YE, et al. Among authors: deeb tz. Front Mol Neurosci. 2019 Jul 23;12:173. doi: 10.3389/fnmol.2019.00173. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31396048 Free PMC article.

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