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Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance.
Wu HM, Yang YV, Huang NJ, Fan LP, Dai YY, Hu KT, Tang TY, Liu L, Xu Y, Liu DT, Cai ZX, Niu XY, Ren XY, Yao ZH, Qin HY, Chen JZ, Huang X, Zhang C, You X, Wang C, He Y, Hong W, Sun YX, Zhan YH, Lin SY. Wu HM, et al. Among authors: huang nj, huang x. Front Neurosci. 2024 Apr 23;18:1368552. doi: 10.3389/fnins.2024.1368552. eCollection 2024. Front Neurosci. 2024. PMID: 38716255 Free PMC article.
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Song L, Liu Z, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC. Song L, et al. Among authors: huang x. Nat Commun. 2020 Nov 17;11(1):5842. doi: 10.1038/s41467-020-19694-w. Nat Commun. 2020. PMID: 33203880 Free PMC article.
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC. Ma T, et al. Among authors: huang x. Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23. Nature. 2022. PMID: 35197629 Free PMC article.
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC. Zhang CS, et al. Among authors: huang x, huang g. Nat Metab. 2022 Oct;4(10):1369-1401. doi: 10.1038/s42255-022-00640-7. Epub 2022 Oct 10. Nat Metab. 2022. PMID: 36217034 Free PMC article.
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC. Wu YQ, et al. Among authors: huang x. Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. Epub 2023 Sep 19. Cell Res. 2023. PMID: 37726403 Free PMC article.
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC. Li M, et al. Among authors: huang x. Cell Res. 2024 Oct;34(10):683-706. doi: 10.1038/s41422-024-00985-6. Epub 2024 Jun 19. Cell Res. 2024. PMID: 38898113 Free PMC article.
The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis.
Zhao W, Ouyang C, Zhang L, Wang J, Zhang J, Zhang Y, Huang C, Xiao Q, Jiang B, Lin F, Zhang C, Zhu M, Xie C, Huang X, Zhang B, Zhao W, He J, Chen S, Liu X, Lin D, Li Q, Wang Z. Zhao W, et al. Among authors: huang c, huang x. Nat Commun. 2024 Aug 28;15(1):7455. doi: 10.1038/s41467-024-51444-0. Nat Commun. 2024. PMID: 39198451 Free PMC article.
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