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Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults, a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
Stubbs BJ, Stephens EB, Senadheera C, Peralta S, Roa-Diaz S, Alexander L, Silverman-Martin W, Garcia TY, Yukawa M, Morris J, Blonquist TM, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: newman jc. medRxiv [Preprint]. 2024 May 5:2024.05.03.24306699. doi: 10.1101/2024.05.03.24306699. medRxiv. 2024. Update in: J Nutr Health Aging. 2024 Sep;28(9):100329. doi: 10.1016/j.jnha.2024.100329 PMID: 38746215 Free PMC article. Updated. Preprint.
A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.
Stephens EB, Senadheera C, Roa-Diaz S, Peralta S, Alexander L, Silverman-Martin W, Yukawa M, Morris J, Johnson JB, Newman JC, Stubbs BJ. Stephens EB, et al. Among authors: newman jc. medRxiv [Preprint]. 2024 Apr 18:2024.04.16.24305925. doi: 10.1101/2024.04.16.24305925. medRxiv. 2024. PMID: 38699344 Free PMC article. Preprint.
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ. Alexander M, et al. Among authors: newman jc. Cell Rep. 2024 Nov 26;43(11):114891. doi: 10.1016/j.celrep.2024.114891. Epub 2024 Nov 4. Cell Rep. 2024. PMID: 39500329 Free article.
Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study.
Stubbs BJ, Stephens EB, Senadheera C, Diaz SR, Peralta S, Alexander L, Silverman-Martin W, Kurtzig J, Fernando BA, Yurkovich JT, Garcia TY, Yukawa M, Morris J, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: newman jc. medRxiv [Preprint]. 2024 Sep 18:2024.09.17.24313811. doi: 10.1101/2024.09.17.24313811. medRxiv. 2024. PMID: 39371165 Free PMC article. Preprint.
Rationale and protocol for a safety, tolerability and feasibility randomized, parallel arm, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
Stubbs BJ, Alvarez Azañedo G, Peralta S, Diaz SR, Gray W, Alexander L, Silverman-Martin W, Garcia TY, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: newman jc. PLoS One. 2024 Sep 18;19(9):e0307951. doi: 10.1371/journal.pone.0307951. eCollection 2024. PLoS One. 2024. PMID: 39292659 Free PMC article.
Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
Stubbs BJ, Stephens EB, Senadheera C, Peralta S, Roa-Diaz S, Alexander L, Silverman-Martin W, Garcia TY, Yukawa M, Morris J, Blonquist TM, Johnson JB, Newman JC. Stubbs BJ, et al. Among authors: newman jc. J Nutr Health Aging. 2024 Sep;28(9):100329. doi: 10.1016/j.jnha.2024.100329. Epub 2024 Aug 12. J Nutr Health Aging. 2024. PMID: 39137624 Free article. Clinical Trial.
Bringing Geroscience into the Mainstream: From Education to Clinical Practice, What Will It Take?
Al-Naggar IM, Campellone KG, Espinoza SE, Justice JN, Orr ME, Kozikowski C, van der Willik O, Thatcher C, Schmader K, Pignolo RJ, Newman JC, Kuchel GA. Al-Naggar IM, et al. Among authors: newman jc. J Gerontol A Biol Sci Med Sci. 2024 Sep 1;79(9):glae020. doi: 10.1093/gerona/glae020. J Gerontol A Biol Sci Med Sci. 2024. PMID: 39126344 No abstract available.
117 results