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Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans.
Benz F, Camara-Wilpert S, Russel J, Wandera KG, Čepaitė R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, Mestre MR, Cuénod A, Aguilà-Sans M, Maccario L, Egli A, Randau L, Pausch P, Rocha EPC, Beisel CL, Madsen JS, Bikard D, Hall AR, Sørensen SJ, Pinilla-Redondo R. Benz F, et al. Among authors: wandera kg. Cell Host Microbe. 2024 Jun 12;32(6):875-886.e9. doi: 10.1016/j.chom.2024.04.016. Epub 2024 May 15. Cell Host Microbe. 2024. PMID: 38754416
Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA.
Dmytrenko O, Neumann GC, Hallmark T, Keiser DJ, Crowley VM, Vialetto E, Mougiakos I, Wandera KG, Domgaard H, Weber J, Gaudin T, Metcalf J, Gray BN, Begemann MB, Jackson RN, Beisel CL. Dmytrenko O, et al. Among authors: wandera kg. Nature. 2023 Jan;613(7944):588-594. doi: 10.1038/s41586-022-05559-3. Epub 2023 Jan 4. Nature. 2023. PMID: 36599979 Free PMC article.