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Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122Δ variant.
Ahmed Y, Nguyen BA, Afrin S, Singh V, Evers B, Singh P, Pedretti R, Wang L, Bassett P, Del Carmen Fernandez-Ramirez M, Pekala M, Kluve-Beckerman B, Saelices L. Ahmed Y, et al. Among authors: singh v, singh p. bioRxiv [Preprint]. 2024 May 10:2024.05.09.593396. doi: 10.1101/2024.05.09.593396. bioRxiv. 2024. PMID: 38766262 Free PMC article. Preprint.
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. Among authors: singh v, singh p. bioRxiv [Preprint]. 2023 Mar 7:2023.03.07.531573. doi: 10.1101/2023.03.07.531573. bioRxiv. 2023. Update in: Nat Chem Biol. 2024 May;20(5):646-655. doi: 10.1038/s41589-024-01551-2 PMID: 36945566 Free PMC article. Updated. Preprint.
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.
Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pękała M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L. Nguyen BA, et al. Among authors: singh v, singh p. Nat Commun. 2024 Jan 17;15(1):581. doi: 10.1038/s41467-024-44820-3. Nat Commun. 2024. PMID: 38233397 Free PMC article.
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. Among authors: singh v, singh p. Nat Chem Biol. 2024 May;20(5):646-655. doi: 10.1038/s41589-024-01551-2. Epub 2024 Feb 12. Nat Chem Biol. 2024. PMID: 38347213 Free PMC article.
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. Among authors: singh v, singh p. Nat Chem Biol. 2024 May;20(5):656. doi: 10.1038/s41589-024-01587-4. Nat Chem Biol. 2024. PMID: 38413747 Free PMC article. No abstract available.
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis.
Nguyen BA, Singh V, Afrin S, Singh P, Pekala M, Ahmed Y, Pedretti R, Canepa J, Lemoff A, Kluve-Beckerman B, Wydorski P, Chhapra F, Saelices L. Nguyen BA, et al. Among authors: singh v, singh p. bioRxiv [Preprint]. 2024 Mar 9:2024.03.08.582936. doi: 10.1101/2024.03.08.582936. bioRxiv. 2024. Update in: Commun Biol. 2024 Jul 27;7(1):905. doi: 10.1038/s42003-024-06588-6 PMID: 38496656 Free PMC article. Updated. Preprint.
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity.
Nguyen BA, Afrin S, Yakubovska A, Singh V, Alicea JV, Kunach P, Singh P, Pekala M, Ahmed Y, Fernandez-Ramirez MDC, Hernandez LOC, Pedretti R, Bassett P, Wang L, Lemoff A, Villalon L, Kluve-Beckerman B, Saelices L. Nguyen BA, et al. Among authors: singh v, singh p. bioRxiv [Preprint]. 2024 May 14:2024.05.14.594028. doi: 10.1101/2024.05.14.594028. bioRxiv. 2024. Update in: Structure. 2024 Oct 9:S0969-2126(24)00421-0. doi: 10.1016/j.str.2024.09.021 PMID: 38798361 Free PMC article. Updated. Preprint.
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM.
Fernandez-Ramirez MDC, Nguyen BA, Singh V, Afrin S, Evers B, Basset P, Wang L, Pękała M, Ahmed Y, Singh P, Canepa J, Wosztyl A, Li Y, Saelices L. Fernandez-Ramirez MDC, et al. Among authors: singh v, singh p. bioRxiv [Preprint]. 2024 May 14:2024.05.14.594218. doi: 10.1101/2024.05.14.594218. bioRxiv. 2024. PMID: 38798519 Free PMC article. Preprint.
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