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Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo.
Gui Y, Kim Y, Brenna S, Wilmes M, Zaghen G, Goulbourne CN, Kuchenbecker-Pöls L, Siebels B, Voß H, Gocke A, Schlüter H, Schweizer M, Altmeppen HC, Magnus T, Levy E, Puig B. Gui Y, et al. Among authors: goulbourne cn. Cell Mol Life Sci. 2024 May 20;81(1):224. doi: 10.1007/s00018-024-05266-4. Cell Mol Life Sci. 2024. PMID: 38769196 Free PMC article.
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome.
D'Acunzo P, Pérez-González R, Kim Y, Hargash T, Miller C, Alldred MJ, Erdjument-Bromage H, Penikalapati SC, Pawlik M, Saito M, Saito M, Ginsberg SD, Neubert TA, Goulbourne CN, Levy E. D'Acunzo P, et al. Among authors: goulbourne cn. Sci Adv. 2021 Feb 12;7(7):eabe5085. doi: 10.1126/sciadv.abe5085. Print 2021 Feb. Sci Adv. 2021. PMID: 33579698 Free PMC article.
Cocaine perturbs mitovesicle biology in the brain.
D'Acunzo P, Ungania JM, Kim Y, Barreto BR, DeRosa S, Pawlik M, Canals-Baker S, Erdjument-Bromage H, Hashim A, Goulbourne CN, Neubert TA, Saito M, Sershen H, Levy E. D'Acunzo P, et al. Among authors: goulbourne cn. J Extracell Vesicles. 2023 Jan;12(1):e12301. doi: 10.1002/jev2.12301. J Extracell Vesicles. 2023. PMID: 36691887 Free PMC article.
Apolipoprotein E4 genotype compromises brain exosome production.
Peng KY, Pérez-González R, Alldred MJ, Goulbourne CN, Morales-Corraliza J, Saito M, Saito M, Ginsberg SD, Mathews PM, Levy E. Peng KY, et al. Among authors: goulbourne cn. Brain. 2019 Jan 1;142(1):163-175. doi: 10.1093/brain/awy289. Brain. 2019. PMID: 30496349 Free PMC article.
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA. Lee JH, et al. Among authors: goulbourne cn. Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. Nat Neurosci. 2022. PMID: 35654956 Free PMC article.
41 results