Eykyn TR - Search Results

1

Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart.

Chung YJ, Hoare Z, Baark F, Yu CS, Guo J, Fuller W, Southworth R, Katschinski DM, Murphy MP, Eykyn TR, Shattock MJ. Chung YJ, et al. Among authors: eykyn tr. Nat Commun. 2024 May 20;15(1):4277. doi: 10.1038/s41467-024-48474-z. Nat Commun. 2024. PMID: 38769288 Free PMC article.

2

Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Aksentijevic D, O'Brien BA, Eykyn TR, Shattock MJ. Aksentijevic D, et al. Among authors: eykyn tr. Biochem Soc Trans. 2018 Aug 20;46(4):817-827. doi: 10.1042/BST20170508. Epub 2018 Jul 3. Biochem Soc Trans. 2018. PMID: 29970448 Free PMC article. Review.

3

Intracellular sodium elevation reprograms cardiac metabolism.

Aksentijević D, Karlstaedt A, Basalay MV, O'Brien BA, Sanchez-Tatay D, Eminaga S, Thakker A, Tennant DA, Fuller W, Eykyn TR, Taegtmeyer H, Shattock MJ. Aksentijević D, et al. Among authors: eykyn tr. Nat Commun. 2020 Aug 28;11(1):4337. doi: 10.1038/s41467-020-18160-x. Nat Commun. 2020. PMID: 32859897 Free PMC article.

4

Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i.

Eykyn TR, Aksentijević D, Aughton KL, Southworth R, Fuller W, Shattock MJ. Eykyn TR, et al. J Mol Cell Cardiol. 2015 Sep;86:95-101. doi: 10.1016/j.yjmcc.2015.07.009. Epub 2015 Jul 18. J Mol Cell Cardiol. 2015. PMID: 26196304 Free PMC article.

5

Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart.

Chung YJ, Park KC, Tokar S, Eykyn TR, Fuller W, Pavlovic D, Swietach P, Shattock MJ. Chung YJ, et al. Among authors: eykyn tr. Cardiovasc Res. 2021 Dec 17;117(14):2794-2806. doi: 10.1093/cvr/cvaa323. Cardiovasc Res. 2021. PMID: 33135077 Free PMC article.

6

SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens.

Chung YJ, Park KC, Tokar S, Eykyn TR, Fuller W, Pavlovic D, Swietach P, Shattock MJ. Chung YJ, et al. Among authors: eykyn tr. Cardiovasc Res. 2021 Dec 17;117(14):2702-2704. doi: 10.1093/cvr/cvab184. Cardiovasc Res. 2021. PMID: 34051094 Free PMC article. No abstract available.

7

Empagliflozin improves cardiac energetics during ischaemia/reperfusion by directly increasing cardiac ketone utilization.

Chase D, Eykyn TR, Shattock MJ, Chung YJ. Chase D, et al. Among authors: eykyn tr. Cardiovasc Res. 2023 Dec 19;119(16):2672-2680. doi: 10.1093/cvr/cvad157. Cardiovasc Res. 2023. PMID: 37819017 Free PMC article.

8

Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.

Faulkes CG, Eykyn TR, Miljkovic JL, Gilbert JD, Charles RL, Prag HA, Patel N, Hart DW, Murphy MP, Bennett NC, Aksentijevic D. Faulkes CG, et al. Among authors: eykyn tr. Nat Commun. 2024 Mar 27;15(1):2204. doi: 10.1038/s41467-024-46470-x. Nat Commun. 2024. PMID: 38538579 Free PMC article.

9

Tissue acidosis does not mediate the hypoxia selectivity of [⁶⁴Cu][Cu(ATSM)] in the isolated perfused rat heart.

Baark F, Shaughnessy F, Pell VR, Clark JE, Eykyn TR, Blower P, Southworth R. Baark F, et al. Among authors: eykyn tr. Sci Rep. 2019 Jan 24;9(1):499. doi: 10.1038/s41598-018-36145-1. Sci Rep. 2019. PMID: 30679497 Free PMC article.

10

Detecting Validated Intracellular ROS Generation with ¹⁸F-dihydroethidine-Based PET.

Waters ECT, Baark F, Yu Z, Mota F, Eykyn TR, Yan R, Southworth R. Waters ECT, et al. Among authors: eykyn tr. Mol Imaging Biol. 2022 Jun;24(3):377-383. doi: 10.1007/s11307-021-01683-0. Epub 2021 Nov 24. Mol Imaging Biol. 2022. PMID: 34820762 Free PMC article.

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