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Enzymatic depletion of circulating glutamine is immunosuppressive in cancers.
Kumar M, Leekha A, Nandy S, Kulkarni R, Martinez-Paniagua M, Rahman Sefat KMS, Willson RC, Varadarajan N. Kumar M, et al. Among authors: varadarajan n. iScience. 2024 Apr 26;27(6):109817. doi: 10.1016/j.isci.2024.109817. eCollection 2024 Jun 21. iScience. 2024. PMID: 38770139 Free PMC article.
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression.
Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, Wagner DL, Brunetti L, Jang A, Baker ML, Varadarajan N, Hegde M, Kim YM, Heisterkamp N, Abdel-Azim H, Ahmed N. Fousek K, et al. Among authors: varadarajan n. Leukemia. 2021 Jan;35(1):75-89. doi: 10.1038/s41375-020-0792-2. Epub 2020 Mar 24. Leukemia. 2021. PMID: 32205861 Free PMC article.
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.
Rath JA, Bajwa G, Carreres B, Hoyer E, Gruber I, Martínez-Paniagua MA, Yu YR, Nouraee N, Sadeghi F, Wu M, Wang T, Hebeisen M, Rufer N, Varadarajan N, Ho PC, Brenner MK, Gfeller D, Arber C. Rath JA, et al. Among authors: varadarajan n. Sci Adv. 2020 Jul 3;6(27):eaaz7809. doi: 10.1126/sciadv.aaz7809. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32923584 Free PMC article.
CD8+ T cells inhibit metastasis and CXCL4 regulates its function.
Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. Joseph R, et al. Among authors: varadarajan n. Br J Cancer. 2021 Jul;125(2):176-189. doi: 10.1038/s41416-021-01338-5. Epub 2021 Apr 1. Br J Cancer. 2021. PMID: 33795809 Free PMC article.
82 results