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Dose escalation study of a personalized peptide-based neoantigen vaccine (EVX-01) in patients with metastatic melanoma.
Mørk SK, Skadborg SK, Albieri B, Draghi A, Bol K, Kadivar M, Westergaard MCW, Stoltenborg Granhøj J, Borch A, Petersen NV, Thuesen N, Rasmussen IS, Andreasen LV, Dohn RB, Yde CW, Noergaard N, Lorentzen T, Soerensen AB, Kleine-Kohlbrecher D, Jespersen A, Christensen D, Kringelum J, Donia M, Hadrup SR, Marie Svane I. Mørk SK, et al. Among authors: borch a. J Immunother Cancer. 2024 May 23;12(5):e008817. doi: 10.1136/jitc-2024-008817. J Immunother Cancer. 2024. PMID: 38782542 Free PMC article.
Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations.
Hansen UK, Ramskov S, Bjerregaard AM, Borch A, Andersen R, Draghi A, Donia M, Bentzen AK, Marquard AM, Szallasi Z, Eklund AC, Svane IM, Hadrup SR. Hansen UK, et al. Among authors: borch a. Front Immunol. 2020 Mar 12;11:373. doi: 10.3389/fimmu.2020.00373. eCollection 2020. Front Immunol. 2020. PMID: 32226429 Free PMC article.
T Cell Epitope Prediction and Its Application to Immunotherapy.
Schaap-Johansen AL, Vujović M, Borch A, Hadrup SR, Marcatili P. Schaap-Johansen AL, et al. Among authors: borch a. Front Immunol. 2021 Sep 15;12:712488. doi: 10.3389/fimmu.2021.712488. eCollection 2021. Front Immunol. 2021. PMID: 34603286 Free PMC article. Review.
Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma.
Kristensen NP, Heeke C, Tvingsholm SA, Borch A, Draghi A, Crowther MD, Carri I, Munk KK, Holm JS, Bjerregaard AM, Bentzen AK, Marquard AM, Szallasi Z, McGranahan N, Andersen R, Nielsen M, Jönsson GB, Donia M, Svane IM, Hadrup SR. Kristensen NP, et al. Among authors: borch a. J Clin Invest. 2022 Jan 18;132(2):e150535. doi: 10.1172/JCI150535. J Clin Invest. 2022. PMID: 34813506 Free PMC article. Clinical Trial.
Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma.
Holm JS, Funt SA, Borch A, Munk KK, Bjerregaard AM, Reading JL, Maher C, Regazzi A, Wong P, Al-Ahmadie H, Iyer G, Tamhane T, Bentzen AK, Herschend NO, De Wolf S, Snyder A, Merghoub T, Wolchok JD, Nielsen M, Rosenberg JE, Bajorin DF, Hadrup SR. Holm JS, et al. Among authors: borch a. Nat Commun. 2022 Apr 11;13(1):1935. doi: 10.1038/s41467-022-29342-0. Nat Commun. 2022. PMID: 35410325 Free PMC article. Clinical Trial.
IMPROVE: a feature model to predict neoepitope immunogenicity through broad-scale validation of T-cell recognition.
Borch A, Carri I, Reynisson B, Alvarez HMG, Munk KK, Montemurro A, Kristensen NP, Tvingsholm SA, Holm JS, Heeke C, Moss KH, Hansen UK, Schaap-Johansen AL, Bagger FO, de Lima VAB, Rohrberg KS, Funt SA, Donia M, Svane IM, Lassen U, Barra C, Nielsen M, Hadrup SR. Borch A, et al. Front Immunol. 2024 Apr 3;15:1360281. doi: 10.3389/fimmu.2024.1360281. eCollection 2024. Front Immunol. 2024. PMID: 38633261 Free PMC article.
Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways.
Skadborg SK, Maarup S, Draghi A, Borch A, Hendriksen S, Mundt F, Pedersen V, Mann M, Christensen IJ, Skjøth-Ramussen J, Yde CW, Kristensen BW, Poulsen HS, Hasselbalch B, Svane IM, Lassen U, Hadrup SR. Skadborg SK, et al. Among authors: borch a. Cancer Immunol Res. 2024 Sep 3;12(9):1202-1220. doi: 10.1158/2326-6066.CIR-23-0959. Cancer Immunol Res. 2024. PMID: 38885356 Free PMC article.
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers.
Saini SK, Ørskov AD, Bjerregaard AM, Unnikrishnan A, Holmberg-Thydén S, Borch A, Jensen KV, Anande G, Bentzen AK, Marquard AM, Tamhane T, Treppendahl MB, Gang AO, Dufva IH, Szallasi Z, Ternette N, Pedersen AG, Eklund AC, Pimanda J, Grønbæk K, Hadrup SR. Saini SK, et al. Among authors: borch a. Nat Commun. 2020 Nov 9;11(1):5660. doi: 10.1038/s41467-020-19464-8. Nat Commun. 2020. PMID: 33168830 Free PMC article.
49 results