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Page 1
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade.
Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. Ibruli O, et al. Among authors: saggau j. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. J Cancer Res Clin Oncol. 2024. PMID: 39542886 Free PMC article.
The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo.
Kelepouras K, Saggau J, Varanda AB, Zrilic M, Kiefer C, Rakhsh-Khorshid H, Lisewski I, Uranga-Murillo I, Arias M, Pardo J, Tonnus W, Linkermann A, Annibaldi A, Walczak H, Liccardi G. Kelepouras K, et al. Among authors: saggau j. Cell Death Differ. 2024 Jul;31(7):897-909. doi: 10.1038/s41418-024-01313-6. Epub 2024 May 23. Cell Death Differ. 2024. PMID: 38783091 Free PMC article.
CDK9 inhibition as an effective therapy for small cell lung cancer.
Valdez Capuccino L, Kleitke T, Szokol B, Svajda L, Martin F, Bonechi F, Krekó M, Azami S, Montinaro A, Wang Y, Nikolov V, Kaiser L, Bonasera D, Saggau J, Scholz T, Schmitt A, Beleggia F, Reinhardt HC, George J, Liccardi G, Walczak H, Tóvári J, Brägelmann J, Montero J, Sos ML, Őrfi L, Peltzer N. Valdez Capuccino L, et al. Among authors: saggau j. Cell Death Dis. 2024 May 20;15(5):345. doi: 10.1038/s41419-024-06724-4. Cell Death Dis. 2024. PMID: 38769311 Free PMC article.
Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality.
Albert MC, Uranga-Murillo I, Arias M, De Miguel D, Peña N, Montinaro A, Varanda AB, Theobald SJ, Areso I, Saggau J, Koch M, Liccardi G, Peltzer N, Rybniker J, Hurtado-Guerrero R, Merino P, Monzón M, Badiola JJ, Reindl-Schwaighofer R, Sanz-Pamplona R, Cebollada-Solanas A, Megyesfalvi Z, Dome B, Secrier M, Hartmann B, Bergmann M, Pardo J, Walczak H. Albert MC, et al. Among authors: saggau j. Cell Death Differ. 2024 May;31(5):544-557. doi: 10.1038/s41418-024-01278-6. Epub 2024 Mar 21. Cell Death Differ. 2024. PMID: 38514848 Free PMC article.
12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration.
Ramos C, Bonasera D, Saggau J, Kabiljo J, Lin P, Tishina S, Rincón MG. Ramos C, et al. Among authors: saggau j. Biochim Biophys Acta Mol Cell Res. 2024 Mar;1871(3):119677. doi: 10.1016/j.bbamcr.2024.119677. Epub 2024 Jan 23. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 38266659 Free article. Review.
LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1.
Vom Stein AF, Rebollido-Rios R, Lukas A, Koch M, von Lom A, Reinartz S, Bachurski D, Rose F, Bozek K, Abdallah AT, Kohlhas V, Saggau J, Zölzer R, Zhao Y, Bruns C, Bröckelmann PJ, Lohneis P, Büttner R, Häupl B, Oellerich T, Nguyen PH, Hallek M. Vom Stein AF, et al. Among authors: saggau j. Nat Commun. 2023 Mar 10;14(1):1330. doi: 10.1038/s41467-023-36824-2. Nat Commun. 2023. PMID: 36899005 Free PMC article.
Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers.
Montinaro A, Areso Zubiaur I, Saggau J, Kretz AL, Ferreira RMM, Hassan O, Kitzig E, Müller I, El-Bahrawy MA, von Karstedt S, Kulms D, Liccardi G, Lemke J, Walczak H. Montinaro A, et al. Among authors: saggau j. Cell Death Differ. 2022 Mar;29(3):492-503. doi: 10.1038/s41418-021-00869-x. Epub 2021 Sep 17. Cell Death Differ. 2022. PMID: 34535764 Free PMC article.