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Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations.
Bantounas I, Rooney KM, Lopes FM, Tengku F, Woods S, Zeef LAH, Lin IH, Kuba SY, Bates N, Hummelgaard S, Hillman KA, Cereghini S, Woolf AS, Kimber SJ. Bantounas I, et al. Among authors: hummelgaard s. Stem Cell Reports. 2024 Jun 11;19(6):859-876. doi: 10.1016/j.stemcr.2024.04.011. Epub 2024 May 23. Stem Cell Reports. 2024. PMID: 38788724 Free PMC article.
Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.
Skeby CK, Hummelgaard S, Gustafsen C, Petrillo F, Frederiksen KP, Olsen D, Kristensen T, Ivarsen P, Madsen P, Christensen EI, Nielsen R, Birn H, Glerup S, Weyer K. Skeby CK, et al. Among authors: hummelgaard s. Kidney Int. 2023 Oct;104(4):754-768. doi: 10.1016/j.kint.2023.06.024. Epub 2023 Jul 3. Kidney Int. 2023. PMID: 37406929 Free article.
Targeting PCSK9 to tackle cardiovascular disease.
Hummelgaard S, Vilstrup JP, Gustafsen C, Glerup S, Weyer K. Hummelgaard S, et al. Pharmacol Ther. 2023 Sep;249:108480. doi: 10.1016/j.pharmthera.2023.108480. Epub 2023 Jun 17. Pharmacol Ther. 2023. PMID: 37331523 Free article. Review.
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus.
Voss LF, Howarth AJ, Wittenborn TR, Hummelgaard S, Juul-Madsen K, Kastberg KS, Pedersen MK, Jensen L, Papanastasiou AD, Vorup-Jensen T, Weyer K, Degn SE. Voss LF, et al. Among authors: hummelgaard s. Front Immunol. 2022 Dec 14;13:1021370. doi: 10.3389/fimmu.2022.1021370. eCollection 2022. Front Immunol. 2022. PMID: 36591222 Free PMC article.