Leffler H - Search Results

1

Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.

Zetterberg FR, Peterson K, Nilsson UJ, Andréasson Dahlgren K, Diehl C, Holyer I, Håkansson M, Khabut A, Kahl-Knutson B, Leffler H, MacKinnon AC, Roper JA, Slack RJ, Zarrizi R, Pedersen A. Zetterberg FR, et al. Among authors: leffler h. J Med Chem. 2024 Jun 13;67(11):9374-9388. doi: 10.1021/acs.jmedchem.4c00485. Epub 2024 May 28. J Med Chem. 2024. PMID: 38804039

2

Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine.

Sörme P, Qian Y, Nyholm PG, Leffler H, Nilsson UJ. Sörme P, et al. Among authors: leffler h. Chembiochem. 2002 Mar 1;3(2-3):183-9. doi: 10.1002/1439-7633(20020301)3:2/3<183::aid-cbic183>3.0.co;2-#. Chembiochem. 2002. PMID: 11921396

3

Fluorescence polarization to study galectin-ligand interactions.

Sörme P, Kahl-Knutson B, Wellmar U, Nilsson UJ, Leffler H. Sörme P, et al. Among authors: leffler h. Methods Enzymol. 2003;362:504-12. doi: 10.1016/S0076-6879(03)01033-4. Methods Enzymol. 2003. PMID: 12968384 No abstract available.

4

Design and synthesis of galectin inhibitors.

Sörme P, Kahl-Knutsson B, Wellmar U, Magnusson BG, Leffler H, Nilsson UJ. Sörme P, et al. Among authors: leffler h. Methods Enzymol. 2003;363:157-69. doi: 10.1016/S0076-6879(03)01050-4. Methods Enzymol. 2003. PMID: 14579574 No abstract available.

5

Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay.

Oberg CT, Carlsson S, Fillion E, Leffler H, Nilsson UJ. Oberg CT, et al. Among authors: leffler h. Bioconjug Chem. 2003 Nov-Dec;14(6):1289-97. doi: 10.1021/bc034130j. Bioconjug Chem. 2003. PMID: 14624646

6

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions.

Sörme P, Kahl-Knutsson B, Huflejt M, Nilsson UJ, Leffler H. Sörme P, et al. Among authors: leffler h. Anal Biochem. 2004 Nov 1;334(1):36-47. doi: 10.1016/j.ab.2004.06.042. Anal Biochem. 2004. PMID: 15464951

7

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.

Sörme P, Arnoux P, Kahl-Knutsson B, Leffler H, Rini JM, Nilsson UJ. Sörme P, et al. Among authors: leffler h. J Am Chem Soc. 2005 Feb 16;127(6):1737-43. doi: 10.1021/ja043475p. J Am Chem Soc. 2005. PMID: 15701008

8

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors.

Tejler J, Leffler H, Nilsson UJ. Tejler J, et al. Among authors: leffler h. Bioorg Med Chem Lett. 2005 May 2;15(9):2343-5. doi: 10.1016/j.bmcl.2005.02.079. Bioorg Med Chem Lett. 2005. PMID: 15837322 Free article.

9

Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7.

Cumpstey I, Carlsson S, Leffler H, Nilsson UJ. Cumpstey I, et al. Among authors: leffler h. Org Biomol Chem. 2005 May 21;3(10):1922-32. doi: 10.1039/b502354h. Epub 2005 Apr 14. Org Biomol Chem. 2005. PMID: 15889175

10

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

Salameh BA, Leffler H, Nilsson UJ. Salameh BA, et al. Among authors: leffler h. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3344-6. doi: 10.1016/j.bmcl.2005.05.084. Bioorg Med Chem Lett. 2005. PMID: 15963723

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