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Page 1
G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits.
Kossatz E, Diez-Alarcia R, Gaitonde SA, Ramon-Duaso C, Stepniewski TM, Aranda-Garcia D, Muneta-Arrate I, Tepaz E, Saen-Oon S, Soliva R, Shahraki A, Moreira D, Brea J, Loza MI, de la Torre R, Kolb P, Bouvier M, Meana JJ, Robledo P, Selent J. Kossatz E, et al. Among authors: gaitonde sa. Nat Commun. 2024 May 29;15(1):4307. doi: 10.1038/s41467-024-48196-2. Nat Commun. 2024. PMID: 38811567 Free PMC article.
Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.
Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J. Ibi D, et al. Among authors: gaitonde sa. Nat Neurosci. 2017 Sep;20(9):1247-1259. doi: 10.1038/nn.4616. Epub 2017 Aug 7. Nat Neurosci. 2017. PMID: 28783139 Free PMC article.
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor.
Gaitonde SA, Avet C, de la Fuente Revenga M, Blondel-Tepaz E, Shahraki A, Pastor AM, Talagayev V, Robledo P, Kolb P, Selent J, González-Maeso J, Bouvier M. Gaitonde SA, et al. Mol Psychiatry. 2024 Sep;29(9):2753-2764. doi: 10.1038/s41380-024-02531-7. Epub 2024 Apr 2. Mol Psychiatry. 2024. PMID: 38561467 Free PMC article.
Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.
Younkin J, Gaitonde SA, Ellaithy A, Vekariya R, Baki L, Moreno JL, Shah S, Drossopoulos P, Hideshima KS, Eltit JM, González-Maeso J, Logothetis DE, Dukat M, Glennon RA. Younkin J, et al. Among authors: gaitonde sa. ACS Chem Neurosci. 2016 Sep 21;7(9):1292-9. doi: 10.1021/acschemneuro.6b00162. Epub 2016 Jul 19. ACS Chem Neurosci. 2016. PMID: 27385190 Free PMC article.
The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions.
Borsdorf S, Zeug A, Wu Y, Mitroshina E, Vedunova M, Gaitonde SA, Bouvier M, Wehr MC, Labus J, Ponimaskin E. Borsdorf S, et al. Among authors: gaitonde sa. Cell Commun Signal. 2024 Nov 23;22(1):563. doi: 10.1186/s12964-024-01931-0. Cell Commun Signal. 2024. PMID: 39580460 Free article.