Craik DJ - Search Results

1

Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors.

Hone AJ, Santiago U, Harvey PJ, Tekarli B, Gajewiak J, Craik DJ, Camacho CJ, McIntosh JM. Hone AJ, et al. Among authors: craik dj. J Med Chem. 2024 Jun 13;67(11):9587-9598. doi: 10.1021/acs.jmedchem.4c00735. Epub 2024 May 30. J Med Chem. 2024. PMID: 38814877

2

Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators.

Nielsen KJ, Skjaerbaek N, Dooley M, Adams DA, Mortensen M, Dodd PR, Craik DJ, Alewood PF, Lewis RJ. Nielsen KJ, et al. Among authors: craik dj. J Med Chem. 1999 Feb 11;42(3):415-26. doi: 10.1021/jm981052q. J Med Chem. 1999. PMID: 9986713

3

Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance.

Gehrmann J, Daly NL, Alewood PF, Craik DJ. Gehrmann J, et al. Among authors: craik dj. J Med Chem. 1999 Jul 1;42(13):2364-72. doi: 10.1021/jm990114p. J Med Chem. 1999. PMID: 10395477

4

alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads.

Dutton JL, Craik DJ. Dutton JL, et al. Among authors: craik dj. Curr Med Chem. 2001 Mar;8(4):327-44. doi: 10.2174/0929867013373453. Curr Med Chem. 2001. PMID: 11172693 Review.

5

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII.

Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Blanchfield JT, et al. Among authors: craik dj. J Med Chem. 2003 Mar 27;46(7):1266-72. doi: 10.1021/jm020426j. J Med Chem. 2003. PMID: 12646037

6

Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter.

Lovelace ES, Armishaw CJ, Colgrave ML, Wahlstrom ME, Alewood PF, Daly NL, Craik DJ. Lovelace ES, et al. Among authors: craik dj. J Med Chem. 2006 Nov 2;49(22):6561-8. doi: 10.1021/jm060299h. J Med Chem. 2006. PMID: 17064074

7

Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function.

Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Jin AH, et al. Among authors: craik dj. J Med Chem. 2008 Sep 25;51(18):5575-84. doi: 10.1021/jm800278k. J Med Chem. 2008. PMID: 18754612

8

Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor.

Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ. Halai R, et al. Among authors: craik dj. J Biol Chem. 2009 Jul 24;284(30):20275-84. doi: 10.1074/jbc.M109.015339. Epub 2009 May 15. J Biol Chem. 2009. PMID: 19447885 Free PMC article.

9

The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant.

Wang CK, Clark RJ, Harvey PJ, Rosengren KJ, Cemazar M, Craik DJ. Wang CK, et al. Among authors: craik dj. Biochemistry. 2011 May 17;50(19):4077-86. doi: 10.1021/bi2004153. Epub 2011 Apr 25. Biochemistry. 2011. PMID: 21466163

10

Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.

Halai R, Callaghan B, Daly NL, Clark RJ, Adams DJ, Craik DJ. Halai R, et al. Among authors: craik dj. J Med Chem. 2011 Oct 13;54(19):6984-92. doi: 10.1021/jm201060r. Epub 2011 Sep 15. J Med Chem. 2011. PMID: 21888386

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