Lin J - Search Results

1

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers.

Miao Y, Bai Y, Miao J, Murray AA, Lin J, Dong J, Qu Z, Zhang RY, Nguyen QD, Wang S, Yu J, Nguele Meke F, Zhang ZY. Miao Y, et al. Among authors: lin j. J Clin Invest. 2024 Jun 6;134(15):e177142. doi: 10.1172/JCI177142. J Clin Invest. 2024. PMID: 38842946 Free PMC article.

2

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.

Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW. Zehender A, et al. Among authors: lin j. Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3. Nat Commun. 2018. PMID: 30108215 Free PMC article.

3

Systemic inhibition of PTPN22 augments anticancer immunity.

Ho WJ, Croessmann S, Lin J, Phyo ZH, Charmsaz S, Danilova L, Mohan AA, Gross NE, Chen F, Dong J, Aggarwal D, Bai Y, Wang J, He J, Leatherman JM, Yarchoan M, Armstrong TD, Zaidi N, Fertig EJ, Denny JC, Park BH, Zhang ZY, Jaffee EM. Ho WJ, et al. Among authors: lin j. J Clin Invest. 2021 Jul 20;131(17):e146950. doi: 10.1172/JCI146950. Online ahead of print. J Clin Invest. 2021. PMID: 34283806 Free PMC article.

4

PTPN22: structure, function, and developments in inhibitor discovery with applications for immunotherapy.

Jassim BA, Lin J, Zhang ZY. Jassim BA, et al. Among authors: lin j. Expert Opin Drug Discov. 2022 Aug;17(8):825-837. doi: 10.1080/17460441.2022.2084607. Epub 2022 Jun 7. Expert Opin Drug Discov. 2022. PMID: 35637605 Free PMC article. Review.

5

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors.

Murphy RD, Chen T, Lin J, He R, Wu L, Pearson CR, Sharma S, Vander Kooi CD, Sinai AP, Zhang ZY, Vander Kooi CW, Gentry MS. Murphy RD, et al. Among authors: lin j. J Biol Chem. 2022 Jul;298(7):102089. doi: 10.1016/j.jbc.2022.102089. Epub 2022 May 28. J Biol Chem. 2022. PMID: 35640720 Free PMC article.

6

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.

Dong J, Miao J, Miao Y, Qu Z, Zhang S, Zhu P, Wiede F, Jassim BA, Bai Y, Nguyen Q, Lin J, Chen L, Tiganis T, Tao WA, Zhang ZY. Dong J, et al. Among authors: lin j. Angew Chem Int Ed Engl. 2023 May 22;62(22):e202303818. doi: 10.1002/anie.202303818. Epub 2023 Apr 21. Angew Chem Int Ed Engl. 2023. PMID: 36973833 Free PMC article.

7

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.

Dong J, Jassim BA, Milholland KL, Qu Z, Bai Y, Miao Y, Miao J, Ma Y, Lin J, Hall MC, Zhang ZY. Dong J, et al. Among authors: lin j. J Med Chem. 2024 Jun 13;67(11):8817-8835. doi: 10.1021/acs.jmedchem.4c00149. Epub 2024 May 20. J Med Chem. 2024. PMID: 38768084

8

Discovery and evaluation of novel SHIP-1 inhibitors.

Miao J, Lin J, Dong J, Amarasinghe O, Mason ER, Chu S, Qu Z, Cullers CC, Putt KS, Zhang ZY. Miao J, et al. Among authors: lin j. Bioorg Med Chem. 2024 Nov 15;114:117965. doi: 10.1016/j.bmc.2024.117965. Epub 2024 Oct 19. Bioorg Med Chem. 2024. PMID: 39454561

9

P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.

Lin J, Sun Y, Huang H, Yu C, Kuang W, Wang Y, Zhu L. Lin J, et al. Mol Neurobiol. 2024 Nov 28. doi: 10.1007/s12035-024-04631-5. Online ahead of print. Mol Neurobiol. 2024. PMID: 39607640

10

The effect of coherent twin boundary migration on the deformation mechanism of Fe-Ni nanowires: molecular dynamics simulation.

Shi W, Cai J, Zhang Y, Lin J. Shi W, et al. Among authors: lin j. RSC Adv. 2024 Nov 27;14(51):37886-37894. doi: 10.1039/d4ra07238c. eCollection 2024 Nov 25. RSC Adv. 2024. PMID: 39606282 Free PMC article.

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