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Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone.
Bartko TM, Lutgen SM, Ross RA, Walisser JA, Garske EP, Kopelke KR, Ashcroft-Hawley K, Tang HM, Kremer JJ, Friedrichs GS, Nichols JV. Bartko TM, et al. Among authors: friedrichs gs. J Pharmacol Toxicol Methods. 2024 Jul-Aug;128:107527. doi: 10.1016/j.vascn.2024.107527. Epub 2024 Jun 8. J Pharmacol Toxicol Methods. 2024. PMID: 38852685 Free article.
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation.
Rossman EI, Cools F, Cordes J, Dhuyvetter D, Doyle JM, Friedrichs GS, Guth B, Neradilek MB, Parish ST, Pierson JB, Polissar N, Tang HM. Rossman EI, et al. Among authors: friedrichs gs. J Pharmacol Toxicol Methods. 2020 Sep;105:106897. doi: 10.1016/j.vascn.2020.106897. Epub 2020 Jul 12. J Pharmacol Toxicol Methods. 2020. PMID: 32663523
Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays.
Brown AP, Friedrichs GS, Tang HM, Traebert M, Weber V, Yao N, Yan GX. Brown AP, et al. Among authors: friedrichs gs. Int J Toxicol. 2024 May-Jun;43(3):231-242. doi: 10.1177/10915818241230900. Epub 2024 Feb 8. Int J Toxicol. 2024. PMID: 38327194
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation.
Friedrichs GS, Abernathy MM, Ackley D, Clark M, DaSilva JK, Foley CM, Greiter-Wilke A, Henderson KA, Kremer JJ, Morimoto BH, Paglialunga S, Pugsley MK, Regan CP, Rossman EI, Segretti JA, Traebert M, Vargas HM, Wisialowski TA. Friedrichs GS, et al. Regul Toxicol Pharmacol. 2024 Nov;153:105706. doi: 10.1016/j.yrtph.2024.105706. Epub 2024 Sep 16. Regul Toxicol Pharmacol. 2024. PMID: 39293707
50 results