Safford HC - Search Results

1

High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route.

Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ. Hamilton AG, et al. Among authors: safford hc. ACS Nano. 2024 Jun 25;18(25):16151-16165. doi: 10.1021/acsnano.4c01171. Epub 2024 Jun 11. ACS Nano. 2024. PMID: 38861479

2

Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy.

Swingle KL, Safford HC, Geisler HC, Hamilton AG, Thatte AS, Billingsley MM, Joseph RA, Mrksich K, Padilla MS, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Swingle KL, et al. Among authors: safford hc. J Am Chem Soc. 2023 Mar 1;145(8):4691-4706. doi: 10.1021/jacs.2c12893. Epub 2023 Feb 15. J Am Chem Soc. 2023. PMID: 36789893 Free PMC article.

3

Rational Design of Nanomedicine for Placental Disorders: Birthing a New Era in Women's Reproductive Health.

Geisler HC, Safford HC, Mitchell MJ. Geisler HC, et al. Among authors: safford hc. Small. 2024 Oct;20(41):e2300852. doi: 10.1002/smll.202300852. Epub 2023 May 16. Small. 2024. PMID: 37191231 Review.

4

Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta.

Safford HC, Swingle KL, Geisler HC, Hamilton AG, Thatte AS, Ghalsasi AA, Billingsley MM, Alameh MG, Weissman D, Mitchell MJ. Safford HC, et al. Small. 2024 Oct;20(41):e2303568. doi: 10.1002/smll.202303568. Epub 2023 Aug 3. Small. 2024. PMID: 37537704

5

In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.

Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ. Billingsley MM, et al. Among authors: safford hc. Small. 2024 Mar;20(11):e2304378. doi: 10.1002/smll.202304378. Epub 2023 Dec 10. Small. 2024. PMID: 38072809

6

Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery.

Patel SK, Billingsley MM, Mukalel AJ, Thatte AS, Hamilton AG, Gong N, El-Mayta R, Safford HC, Merolle M, Mitchell MJ. Patel SK, et al. Among authors: safford hc. Theranostics. 2024 Jan 1;14(1):1-16. doi: 10.7150/thno.89913. eCollection 2024. Theranostics. 2024. PMID: 38164140 Free PMC article.

7

EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta.

Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ. Geisler HC, et al. Among authors: safford hc. J Control Release. 2024 Jul;371:455-469. doi: 10.1016/j.jconrel.2024.05.036. Epub 2024 Jun 10. J Control Release. 2024. PMID: 38789090

8

Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing.

Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ. Palanki R, et al. Among authors: safford hc. Lab Chip. 2024 Aug 6;24(16):3790-3801. doi: 10.1039/d4lc00283k. Lab Chip. 2024. PMID: 39037068 Free PMC article.

9

In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells.

Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH. Palanki R, et al. Among authors: safford hc. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2400783121. doi: 10.1073/pnas.2400783121. Epub 2024 Jul 30. Proc Natl Acad Sci U S A. 2024. PMID: 39078677

10

Oxidized mRNA Lipid Nanoparticles for In Situ Chimeric Antigen Receptor Monocyte Engineering.

Mukalel AJ, Hamilton AG, Billingsley MM, Li J, Thatte AS, Han X, Safford HC, Padilla MS, Papp T, Parhiz H, Weissman D, Mitchell MJ. Mukalel AJ, et al. Among authors: safford hc. Adv Funct Mater. 2024 Jul 3;34(27):2312038. doi: 10.1002/adfm.202312038. Epub 2024 Mar 5. Adv Funct Mater. 2024. PMID: 39628840

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