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descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques.
Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama R, Iwata Y, Shiokawa T, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rosales Rocabado JM, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga JI, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H, Susaki EA. Otomo K, et al. Among authors: hayakawa y. Nat Commun. 2024 Jun 12;15(1):4941. doi: 10.1038/s41467-024-49131-1. Nat Commun. 2024. PMID: 38866781 Free PMC article.
Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway.
Nakai K, Lin H, Yamano S, Tanaka S, Kitamoto S, Saitoh H, Sakuma K, Kurauchi J, Akter E, Konno M, Ishibashi K, Kamata R, Ohashi A, Koseki J, Takahashi H, Yokoyama H, Shiraki Y, Enomoto A, Abe S, Hayakawa Y, Ushiku T, Mutoh M, Fujita Y, Kon S. Nakai K, et al. Among authors: hayakawa y. Nat Commun. 2023 Nov 3;14(1):7048. doi: 10.1038/s41467-023-42774-6. Nat Commun. 2023. PMID: 37923722 Free PMC article.
Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target.
Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M. Arai J, et al. Among authors: hayakawa y. Gastroenterology. 2024 Aug;167(3):505-521.e19. doi: 10.1053/j.gastro.2024.03.037. Epub 2024 Apr 6. Gastroenterology. 2024. PMID: 38583723
Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.
Dubeykovskaya Z, Si Y, Chen X, Worthley DL, Renz BW, Urbanska AM, Hayakawa Y, Xu T, Westphalen CB, Dubeykovskiy A, Chen D, Friedman RA, Asfaha S, Nagar K, Tailor Y, Muthupalani S, Fox JG, Kitajewski J, Wang TC. Dubeykovskaya Z, et al. Among authors: hayakawa y. Nat Commun. 2016 Feb 4;7:10517. doi: 10.1038/ncomms10517. Nat Commun. 2016. PMID: 26841680 Free PMC article.
Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche.
Middelhoff M, Nienhüser H, Valenti G, Maurer HC, Hayakawa Y, Takahashi R, Kim W, Jiang Z, Malagola E, Cuti K, Tailor Y, Zamechek LB, Renz BW, Quante M, Yan KS, Wang TC. Middelhoff M, et al. Among authors: hayakawa y. Nat Commun. 2020 Jan 8;11(1):111. doi: 10.1038/s41467-019-13850-7. Nat Commun. 2020. PMID: 31913277 Free PMC article.
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
Takahashi R, Hirata Y, Sakitani K, Nakata W, Kinoshita H, Hayakawa Y, Nakagawa H, Sakamoto K, Hikiba Y, Ijichi H, Moses HL, Maeda S, Koike K. Takahashi R, et al. Among authors: hayakawa y. Cancer Sci. 2013 Mar;104(3):337-44. doi: 10.1111/cas.12080. Epub 2013 Jan 24. Cancer Sci. 2013. PMID: 23237571 Free PMC article.
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S, Koike K. Hayakawa Y, et al. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):780-5. doi: 10.1073/pnas.1011418108. Epub 2010 Dec 27. Proc Natl Acad Sci U S A. 2011. PMID: 21187402 Free PMC article.
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa T, Hikiba Y, Akanuma M, Shibata W, Maeda S, Koike K. Kinoshita H, et al. Among authors: hayakawa y. PLoS One. 2013 Apr 12;8(4):e60914. doi: 10.1371/journal.pone.0060914. Print 2013. PLoS One. 2013. PMID: 23593346 Free PMC article.
Machine learning-based personalized prediction of gastric cancer incidence using the endoscopic and histologic findings at the initial endoscopy.
Arai J, Aoki T, Sato M, Niikura R, Suzuki N, Ishibashi R, Tsuji Y, Yamada A, Hirata Y, Ushiku T, Hayakawa Y, Fujishiro M. Arai J, et al. Among authors: hayakawa y. Gastrointest Endosc. 2022 May;95(5):864-872. doi: 10.1016/j.gie.2021.12.033. Epub 2022 Jan 5. Gastrointest Endosc. 2022. PMID: 34998795 Clinical Trial.
1,192 results