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An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.
Waterbury AL, Kwok HS, Lee C, Narducci DN, Freedy AM, Su C, Raval S, Reiter AH, Hawkins W, Lee K, Li J, Hoenig SM, Vinyard ME, Cole PA, Hansen AS, Carr SA, Papanastasiou M, Liau BB. Waterbury AL, et al. Among authors: lee k, lee c. Mol Cell. 2024 Jun 20;84(12):2238-2254.e11. doi: 10.1016/j.molcel.2024.05.017. Epub 2024 Jun 12. Mol Cell. 2024. PMID: 38870936
Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
Wang ZA, Markert JW, Whedon SD, Yapa Abeywardana M, Lee K, Jiang H, Suarez C, Lin H, Farnung L, Cole PA. Wang ZA, et al. Among authors: lee k. J Am Chem Soc. 2023 Mar 29;145(12):6811-6822. doi: 10.1021/jacs.2c13512. Epub 2023 Mar 17. J Am Chem Soc. 2023. PMID: 36930461 Free PMC article.
Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
Yeo MJ, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N. Yeo MJ, et al. Among authors: lee k, lee c. bioRxiv [Preprint]. 2024 May 14:2024.05.14.593897. doi: 10.1101/2024.05.14.593897. bioRxiv. 2024. PMID: 38798619 Free PMC article. Preprint.
Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1.
Lee K, Barone M, Waterbury AL, Jiang H, Nam E, DuBois-Coyne SE, Whedon SD, Wang ZA, Caroli J, Neal K, Ibeabuchi B, Dhoondia Z, Kuroda MI, Liau BB, Beck S, Mattevi A, Cole PA. Lee K, et al. Nat Chem Biol. 2024 Jul 4. doi: 10.1038/s41589-024-01671-9. Online ahead of print. Nat Chem Biol. 2024. PMID: 38965385
Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity.
Abeywardana MY, Whedon SD, Lee K, Nam E, Dovarganes R, DuBois-Coyne S, Haque IA, Wang ZA, Cole PA. Abeywardana MY, et al. Among authors: lee k. J Biol Chem. 2024 Sep;300(9):107722. doi: 10.1016/j.jbc.2024.107722. Epub 2024 Aug 28. J Biol Chem. 2024. PMID: 39214297 Free PMC article.
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