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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Richard J, Grunst MW, Niu L, Díaz-Salinas MA, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Yang D, Chiu TJ, Chen HC, Benlarbi M; Guillaume-Beaudoin-Buissières; Gottumukkala S, Li W, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB 3rd, Mothes W, Munro JB, Pazgier M, Finzi A. Richard J, et al. Among authors: diaz salinas ma. bioRxiv [Preprint]. 2024 Aug 27:2024.08.27.609961. doi: 10.1101/2024.08.27.609961. bioRxiv. 2024. PMID: 39253431 Free PMC article. Preprint.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T-J, Chen H-C, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: diaz salinas ma. J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24. Epub 2024 Sep 9. J Virol. 2024. PMID: 39248460
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T, Chen HC, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: diaz salinas ma. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597978. doi: 10.1101/2024.06.07.597978. bioRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24 PMID: 38895270 Free PMC article. Updated. Preprint.
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