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Page 1
Structure and repair of replication-coupled DNA breaks.
Pavani R, Tripathi V, Vrtis KB, Zong D, Chari R, Callen E, Pankajam AV, Zhen G, Matos-Rodrigues G, Yang J, Wu S, Reginato G, Wu W, Cejka P, Walter JC, Nussenzweig A. Pavani R, et al. Among authors: chari r. Science. 2024 Aug 16;385(6710):eado3867. doi: 10.1126/science.ado3867. Epub 2024 Aug 16. Science. 2024. PMID: 38900911
The dystonia gene THAP1 controls DNA double-strand break repair choice.
Shinoda K, Zong D, Callen E, Wu W, Dumitrache LC, Belinky F, Chari R, Wong N, Ishikawa M, Stanlie A, Multhaupt-Buell T, Sharma N, Ozelius L, Ehrlich M, McKinnon PJ, Nussenzweig A. Shinoda K, et al. Among authors: chari r. Mol Cell. 2021 Jun 17;81(12):2611-2624.e10. doi: 10.1016/j.molcel.2021.03.034. Epub 2021 Apr 14. Mol Cell. 2021. PMID: 33857404 Free PMC article.
Active DNA demethylation promotes cell fate specification and the DNA damage response.
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Wang D, et al. Among authors: chari r. Science. 2022 Dec 2;378(6623):983-989. doi: 10.1126/science.add9838. Epub 2022 Dec 1. Science. 2022. PMID: 36454826 Free PMC article.
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
Rathkey D, Khanal M, Murai J, Zhang J, Sengupta M, Jiang Q, Morrow B, Evans CN, Chari R, Fetsch P, Chung HJ, Xi L, Roth M, Filie A, Raffeld M, Thomas A, Pommier Y, Hassan R. Rathkey D, et al. Among authors: chari r. J Thorac Oncol. 2020 May;15(5):843-859. doi: 10.1016/j.jtho.2020.01.012. Epub 2020 Jan 28. J Thorac Oncol. 2020. PMID: 32004714 Free PMC article.
Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: A synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency.
Kim O, Butler M, Sergi Z, Robey RW, Zhang M, Chari R, Pang Y, Yu G, Zhang W, Song H, Davis D, Hawley RG, Wen X, Wang H, Quezado M, Tran B, Merchant M, Ranjan A, Furnari FB, Khan J, Gilbert MR, Ryan Miller C, Gottesman MM, Pommier Y, Wu J. Kim O, et al. Among authors: chari r. Neurooncol Adv. 2023 Aug 21;5(1):vdad102. doi: 10.1093/noajnl/vdad102. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 37706203 Free PMC article.
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: chari r. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
370 results