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Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents.
Roa P, Foglizzo V, Harada G, Repetto M, Kulick A, de Stanchina E, de Marchena M, Auwardt S, Sayed Ahmed S, Bremer NV, Yang SR, Feng Y, Zhou C, Kong N, Liang R, Xu H, Zhang B, Bardelli A, Toska E, Ventura A, Drilon A, Cocco E. Roa P, et al. Among authors: harada g. Br J Cancer. 2024 Aug;131(3):601-610. doi: 10.1038/s41416-024-02760-1. Epub 2024 Jun 20. Br J Cancer. 2024. PMID: 38902532 Free PMC article.
TKI type switching overcomes ROS1 L2086F in ROS1 fusion-positive cancers.
Thawani R, Repetto M, Keddy C, Nicholson K, Jones K, Nusser K, Beach CZ, Harada G, Drilon A, Davare MA. Thawani R, et al. Among authors: harada g. NPJ Precis Oncol. 2024 Aug 8;8(1):175. doi: 10.1038/s41698-024-00663-1. NPJ Precis Oncol. 2024. PMID: 39117775 Free PMC article.
Basket Trials: Past, Present, and Future.
Murciano-Goroff YR, Uppal M, Chen M, Harada G, Schram AM. Murciano-Goroff YR, et al. Among authors: harada g. Annu Rev Cancer Biol. 2024 Jun;8(1):59-80. doi: 10.1146/annurev-cancerbio-061421-012927. Epub 2023 Dec 5. Annu Rev Cancer Biol. 2024. PMID: 38938274 Free PMC article.
113 results