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19 results

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Page 1
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP.
Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, Kagiou C, Hannich JT, Mayor-Ruiz C, Superti-Furga G, Sievers S, Forrester A, Laraia L, Waldmann H, Winter GE. Cigler M, et al. Among authors: mayor ruiz c. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01614-4. Online ahead of print. Nat Chem Biol. 2024. PMID: 38907113
Application of induced proximity for therapeutic discovery.
Cacace A, Daniels D, Ferguson FM, Mayor-Ruiz C, Woo C. Cacace A, et al. Among authors: mayor ruiz c. Cell Chem Biol. 2024 Jun 20;31(6):1036-1038. doi: 10.1016/j.chembiol.2024.05.015. Cell Chem Biol. 2024. PMID: 38906107
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.
Barbosa BMG, Sfyaki A, Rafael S, José-Duran F, Pous J, Sánchez-Zarzalejo C, Perez-Lopez C, Vilanova M, Cigler M, Gay M, Vilaseca M, Winter GE, Riera A, Mayor-Ruiz C. Barbosa BMG, et al. Among authors: mayor ruiz c. Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202316730. doi: 10.1002/anie.202316730. Epub 2024 Jan 18. Angew Chem Int Ed Engl. 2024. PMID: 38153885
Proximity-inducing pharmacology.
Winter GE, Mayor-Ruiz C. Winter GE, et al. Among authors: mayor ruiz c. Nat Chem Biol. 2024 Jan;20(1):13-14. doi: 10.1038/s41589-023-01492-2. Nat Chem Biol. 2024. PMID: 37978259 Free article. No abstract available.
Design principles for cyclin K molecular glue degraders.
Kozicka Z, Suchyta DJ, Focht V, Kempf G, Petzold G, Jentzsch M, Zou C, Di Genua C, Donovan KA, Coomar S, Cigler M, Mayor-Ruiz C, Schmid-Burgk JL, Häussinger D, Winter GE, Fischer ES, Słabicki M, Gillingham D, Ebert BL, Thomä NH. Kozicka Z, et al. Among authors: mayor ruiz c. Nat Chem Biol. 2024 Jan;20(1):93-102. doi: 10.1038/s41589-023-01409-z. Epub 2023 Sep 7. Nat Chem Biol. 2024. PMID: 37679459 Free PMC article.
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.
González L, Díaz L, Pous J, Baginski B, Duran-Corbera A, Scarpa M, Brun-Heath I, Igea A, Martin-Malpartida P, Ruiz L, Pallara C, Esguerra M, Colizzi F, Mayor-Ruiz C, Biondi RM, Soliva R, Macias MJ, Orozco M, Nebreda AR. González L, et al. Among authors: mayor ruiz c. Nat Commun. 2023 Jun 12;14(1):3318. doi: 10.1038/s41467-023-39051-x. Nat Commun. 2023. PMID: 37308482 Free PMC article.
Chasing molecular glue degraders: screening approaches.
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C. Domostegui A, et al. Among authors: mayor ruiz c. Chem Soc Rev. 2022 Jul 4;51(13):5498-5517. doi: 10.1039/d2cs00197g. Chem Soc Rev. 2022. PMID: 35723413 Review.
19 results