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Page 1
Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Palmer N, Agnew C, Benn C, Buffham WJ, Castro JN, Chessari G, Clark M, Cons BD, Coyle JE, Dawson LA, Hamlett CCF, Hodson C, Holding F, Johnson CN, Liebeschuetz JW, Mahajan P, McCarthy JM, Murray CW, O'Reilly M, Peakman T, Price A, Rapti M, Reeks J, Schöpf P, St-Denis JD, Valenzano C, Wallis NG, Walser R, Weir H, Wilsher NE, Woodhead A, Bento CF, Tisi D. Palmer N, et al. Among authors: bento cf. J Med Chem. 2024 Jul 11;67(13):11168-11181. doi: 10.1021/acs.jmedchem.4c00702. Epub 2024 Jun 27. J Med Chem. 2024. PMID: 38932616
The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1.
Gustavsson EK, Sethi S, Gao Y, Brenton JW, García-Ruiz S, Zhang D, Garza R, Reynolds RH, Evans JR, Chen Z, Grant-Peters M, Macpherson H, Montgomery K, Dore R, Wernick AI, Arber C, Wray S, Gandhi S, Esselborn J, Blauwendraat C, Douse CH, Adami A, Atacho DAM, Kouli A, Quaegebeur A, Barker RA, Englund E, Platt F, Jakobsson J, Wood NW, Houlden H, Saini H, Bento CF, Hardy J, Ryten M. Gustavsson EK, et al. Among authors: bento cf. Sci Adv. 2024 Jun 28;10(26):eadk1296. doi: 10.1126/sciadv.adk1296. Epub 2024 Jun 26. Sci Adv. 2024. PMID: 38924406 Free PMC article.
Vinexin contributes to autophagic decline in brain ageing across species.
Park SJ, Frake RA, Karabiyik C, Son SM, Siddiqi FH, Bento CF, Sterk P, Vicinanza M, Pavel M, Rubinsztein DC. Park SJ, et al. Among authors: bento cf. Cell Death Differ. 2022 May;29(5):1055-1070. doi: 10.1038/s41418-021-00903-y. Epub 2021 Nov 30. Cell Death Differ. 2022. PMID: 34848853 Free PMC article.
Polyglutamine tracts regulate autophagy.
Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC. Ashkenazi A, et al. Among authors: bento cf. Autophagy. 2017 Sep 2;13(9):1613-1614. doi: 10.1080/15548627.2017.1336278. Epub 2017 Jul 19. Autophagy. 2017. PMID: 28722507 Free PMC article.
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC. Ashkenazi A, et al. Among authors: bento cf. Nature. 2017 May 4;545(7652):108-111. doi: 10.1038/nature22078. Epub 2017 Apr 26. Nature. 2017. PMID: 28445460 Free PMC article.
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Füllgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC. Menzies FM, et al. Among authors: bento cf. Neuron. 2017 Mar 8;93(5):1015-1034. doi: 10.1016/j.neuron.2017.01.022. Neuron. 2017. PMID: 28279350 Free article. Review.
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