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Page 1
Discovery of a novel inhibitor of macropinocytosis with antiviral activity.
Porebski B, Christ W, Corman A, Haraldsson M, Barz M, Lidemalm L, Häggblad M, Ilmain J, Wright SC, Murga M, Schlegel J, Jarvius M, Lapins M, Sezgin E, Bhabha G, Lauschke VM, Carreras-Puigvert J, Lafarga M, Klingström J, Hühn D, Fernandez-Capetillo O. Porebski B, et al. Among authors: fernandez capetillo o. Mol Ther. 2024 Sep 4;32(9):3012-3024. doi: 10.1016/j.ymthe.2024.06.038. Epub 2024 Jul 2. Mol Ther. 2024. PMID: 38956870 Free PMC article.
A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens.
Schlegel J, Porebski B, Andronico L, Hanke L, Edwards S, Brismar H, Murrell B, McInerney GM, Fernandez-Capetillo O, Sezgin E. Schlegel J, et al. Among authors: fernandez capetillo o. Nano Lett. 2023 May 10;23(9):3701-3707. doi: 10.1021/acs.nanolett.2c04884. Epub 2023 Mar 9. Nano Lett. 2023. PMID: 36892970 Free PMC article.
The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ.
Li X, Hernandez I, Koyuncu S, Kis B, Häggblad M, Lidemalm L, Abbas AA, Bendegúz S, Göblös A, Brautigam L, Lucas JJ, Carreras-Puigvert J, Hühn D, Pircs K, Vilchez D, Fernandez-Capetillo O. Li X, et al. Among authors: fernandez capetillo o. EBioMedicine. 2024 May;103:105124. doi: 10.1016/j.ebiom.2024.105124. Epub 2024 May 2. EBioMedicine. 2024. PMID: 38701619 Free PMC article.
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.
Kanellis DC, Zisi A, Skrott Z, Lemmens B, Espinoza JA, Kosar M, Björkman A, Li X, Arampatzis S, Bartkova J, Andújar-Sánchez M, Fernandez-Capetillo O, Mistrik M, Lindström MS, Bartek J. Kanellis DC, et al. Among authors: fernandez capetillo o. Cell Death Differ. 2023 Jul;30(7):1666-1678. doi: 10.1038/s41418-023-01167-4. Epub 2023 May 4. Cell Death Differ. 2023. PMID: 37142656 Free PMC article.
Cyclophilin D plays a critical role in the survival of senescent cells.
Protasoni M, López-Polo V, Stephan-Otto Attolini C, Brandariz J, Herranz N, Mateo J, Ruiz S, Fernandez-Capetillo O, Kovatcheva M, Serrano M. Protasoni M, et al. Among authors: fernandez capetillo o. EMBO J. 2024 Dec;43(23):5972-6000. doi: 10.1038/s44318-024-00259-2. Epub 2024 Oct 24. EMBO J. 2024. PMID: 39448884 Free PMC article.
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis.
Murga M, Lopez-Pernas G, Soliva R, Fueyo-Marcos E, Amor C, Faustino I, Serna M, Serrano AG, Díaz L, Martínez S, Blanco-Aparicio C, Antón ME, Seashore-Ludlow B, Pastor J, Jafari R, Lafarga M, Llorca O, Orozco M, Fernández-Capetillo O. Murga M, et al. Among authors: fernandez capetillo o. Cell Death Dis. 2024 Sep 28;15(9):694. doi: 10.1038/s41419-024-07106-6. Cell Death Dis. 2024. PMID: 39341827 Free PMC article.
Decoding protein methylation function with thermal stability analysis.
Sayago C, Sánchez-Wandelmer J, García F, Hurtado B, Lafarga V, Prieto P, Zarzuela E, Ximénez-Embún P, Ortega S, Megías D, Fernández-Capetillo O, Malumbres M, Munoz J. Sayago C, et al. Among authors: fernandez capetillo o. Nat Commun. 2023 May 25;14(1):3016. doi: 10.1038/s41467-023-38863-1. Nat Commun. 2023. PMID: 37230995 Free PMC article.
125 results