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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Shepard RM, et al. Among authors: kirchberger nc. Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887. Epub 2024 Jul 3. Sci Transl Med. 2024. PMID: 38959328 Free PMC article.
Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer.
Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate B, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Blise KE, et al. bioRxiv [Preprint]. 2023 Oct 23:2023.10.20.563335. doi: 10.1101/2023.10.20.563335. bioRxiv. 2023. Update in: Cancer Immunol Res. 2024 May 2;12(5):544-558. doi: 10.1158/2326-6066.CIR-23-0873. PMID: 37961410 Free PMC article. Updated. Preprint.
MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.
Doha ZO, Wang X, Calistri NL, Eng J, Daniel CJ, Ternes L, Kim EN, Pelz C, Munks M, Betts C, Kwon S, Bucher E, Li X, Waugh T, Tatarova Z, Blumberg D, Ko A, Kirchberger N, Pietenpol JA, Sanders ME, Langer EM, Dai MS, Mills G, Chin K, Chang YH, Coussens LM, Gray JW, Heiser LM, Sears RC. Doha ZO, et al. Nat Commun. 2023 Sep 13;14(1):5665. doi: 10.1038/s41467-023-40841-6. Nat Commun. 2023. PMID: 37704631 Free PMC article.