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Page 1
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR.
Ople RS, Ramos-Gonzalez N, Li Q, Sobecks BL, Aydin D, Powers AS, Faouzi A, Polacco BJ, Bernhard SM, Appourchaux K, Sribhashyam S, Eans SO, Tsai BA, Dror RO, Varga BR, Wang H, Hüttenhain R, McLaughlin JP, Majumdar S. Ople RS, et al. Among authors: appourchaux k. ACS Cent Sci. 2024 Jul 17;10(8):1490-1503. doi: 10.1021/acscentsci.4c00525. eCollection 2024 Aug 28. ACS Cent Sci. 2024. PMID: 39220695 Free PMC article.
Structure-Guided Design of Partial Agonists at an Opioid Receptor.
Che T, Varga B, Bernhard SM, El Daibani A, Zaidi S, Lam J, Aguilar J, Appourchaux K, Nazarova A, Kouvelis A, Eans S, Margolis E, Fay J, Pradhan A, Katritch V, McLaughlin J, Majumdar S. Che T, et al. Among authors: appourchaux k. Res Sq [Preprint]. 2024 Jul 16:rs.3.rs-4664764. doi: 10.21203/rs.3.rs-4664764/v1. Res Sq. 2024. PMID: 39070616 Free PMC article. Preprint.
A µ-opioid receptor modulator that works cooperatively with naloxone.
O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK. O'Brien ES, et al. Among authors: appourchaux k. Nature. 2024 Jul;631(8021):686-693. doi: 10.1038/s41586-024-07587-7. Epub 2024 Jul 3. Nature. 2024. PMID: 38961287
Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW. Muratspahić E, et al. Among authors: appourchaux k. Nat Commun. 2023 Dec 6;14(1):8064. doi: 10.1038/s41467-023-43718-w. Nat Commun. 2023. PMID: 38052802 Free PMC article.
Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor.
Hennessy MR, Gutridge AM, French AR, Rhoda ES, Meqbil YJ, Gill M, Kashyap Y, Appourchaux K, Paul B, Wang ZJ, van Rijn RM, Riley AP. Hennessy MR, et al. Among authors: appourchaux k. J Med Chem. 2023 Mar 9;66(5):3312-3326. doi: 10.1021/acs.jmedchem.2c01707. Epub 2023 Feb 24. J Med Chem. 2023. PMID: 36827198 Free PMC article.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Among authors: appourchaux k. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists.
Griffett K, Hayes M, Bedia-Diaz G, Appourchaux K, Sanders R, Boeckman MP, Koelblen T, Zhang J, Schulman IG, Elgendy B, Burris TP. Griffett K, et al. Among authors: appourchaux k. ACS Chem Biol. 2022 May 20;17(5):1143-1154. doi: 10.1021/acschembio.2c00057. Epub 2022 Apr 13. ACS Chem Biol. 2022. PMID: 35417135
Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom.
Chakraborty S, Uprety R, Daibani AE, Rouzic VL, Hunkele A, Appourchaux K, Eans SO, Nuthikattu N, Jilakara R, Thammavong L, Pasternak GW, Pan YX, McLaughlin JP, Che T, Majumdar S. Chakraborty S, et al. Among authors: appourchaux k. ACS Chem Neurosci. 2021 Jul 21;12(14):2661-2678. doi: 10.1021/acschemneuro.1c00149. Epub 2021 Jul 2. ACS Chem Neurosci. 2021. PMID: 34213886 Free PMC article.
Generation of adult human T-cell progenitors for immunotherapeutic applications.
Simons L, Ma K, de Chappedelaine C, Moiranghtem RD, Elkaim E, Olivré J, Susini S, Appourchaux K, Reimann C, Sadek H, Pellé O, Cagnard N, Magrin E, Lagresle-Peyrou C, Taghon T, Rausell A, Cavazzana M, André-Schmutz I. Simons L, et al. Among authors: appourchaux k. J Allergy Clin Immunol. 2018 Apr;141(4):1491-1494.e4. doi: 10.1016/j.jaci.2017.10.034. Epub 2017 Dec 5. J Allergy Clin Immunol. 2018. PMID: 29208547 Free PMC article. No abstract available.
17 results