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A µ-opioid receptor modulator that works cooperatively with naloxone.
O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK. O'Brien ES, et al. Among authors: huang w. Nature. 2024 Jul;631(8021):686-693. doi: 10.1038/s41586-024-07587-7. Epub 2024 Jul 3. Nature. 2024. PMID: 38961287
Propagation of conformational changes during μ-opioid receptor activation.
Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. Sounier R, et al. Among authors: huang w. Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680. Epub 2015 Aug 5. Nature. 2015. PMID: 26245377 Free PMC article.
Conformational transitions of a neurotensin receptor 1-Gi1 complex.
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Kato HE, et al. Among authors: huang w. Nature. 2019 Aug;572(7767):80-85. doi: 10.1038/s41586-019-1337-6. Epub 2019 Jun 26. Nature. 2019. PMID: 31243364 Free PMC article.
Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK. Huang W, et al. Nature. 2020 Mar;579(7798):303-308. doi: 10.1038/s41586-020-1953-1. Epub 2020 Jan 16. Nature. 2020. PMID: 31945771 Free PMC article.
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G. Qu Q, et al. Among authors: huang w. Nat Chem Biol. 2023 Apr;19(4):423-430. doi: 10.1038/s41589-022-01208-y. Epub 2022 Nov 21. Nat Chem Biol. 2023. PMID: 36411392 Free PMC article.
Structural insights into µ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5. Nature. 2015. PMID: 26245379 Free PMC article.
Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists.
Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK, Gmeiner P. Wang H, et al. Among authors: huang w. Angew Chem Int Ed Engl. 2022 Jun 27;61(26):e202200269. doi: 10.1002/anie.202200269. Epub 2022 Apr 29. Angew Chem Int Ed Engl. 2022. PMID: 35385593 Free PMC article.
Author Correction: Structural insights into μ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Nature. 2020 Aug;584(7820):E16. doi: 10.1038/s41586-020-2542-z. Nature. 2020. PMID: 32724208
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.
Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK. Korczynska M, et al. Among authors: huang w. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428. doi: 10.1073/pnas.1718037115. Epub 2018 Feb 16. Proc Natl Acad Sci U S A. 2018. PMID: 29453275 Free PMC article.
Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization.
Bae HE, Cecchetti C, Du Y, Katsube S, Mortensen JS, Huang W, Rehan S, Lee HJ, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Bae HE, et al. Among authors: huang w. Acta Biomater. 2020 Aug;112:250-261. doi: 10.1016/j.actbio.2020.06.001. Epub 2020 Jun 6. Acta Biomater. 2020. PMID: 32522715 Free PMC article.
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