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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Specker E, Wesolowski R, Schütz A, Matthes S, Mallow K, Wasinska-Kalwa M, Winkler L, Oder A, Alenina N, Pleimes D, von Kries JP, Heinemann U, Bader M, Nazaré M. Specker E, et al. Among authors: heinemann u. J Med Chem. 2023 Nov 9;66(21):14866-14896. doi: 10.1021/acs.jmedchem.3c01454. Epub 2023 Oct 31. J Med Chem. 2023. PMID: 37905925
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem N, Roske Y, Kovalskyy D, Platonov MO, Balinskyi O, Kreuchwig A, Saupe J, Fang L, Diehl A, Schmieder P, Krause G, Rademann J, Heinemann U, Birchmeier W, Oschkinat H. Kamdem N, et al. Among authors: heinemann u. Magn Reson (Gott). 2021 Jun 2;2(1):355-374. doi: 10.5194/mr-2-355-2021. eCollection 2021. Magn Reson (Gott). 2021. PMID: 37904770 Free PMC article.
TapA acts as specific chaperone in TasA filament formation by strand complementation.
Roske Y, Lindemann F, Diehl A, Cremer N, Higman VA, Schlegel B, Leidert M, Driller K, Turgay K, Schmieder P, Heinemann U, Oschkinat H. Roske Y, et al. Among authors: heinemann u. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2217070120. doi: 10.1073/pnas.2217070120. Epub 2023 Apr 17. Proc Natl Acad Sci U S A. 2023. PMID: 37068239 Free PMC article.
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
Specker E, Matthes S, Wesolowski R, Schütz A, Grohmann M, Alenina N, Pleimes D, Mallow K, Neuenschwander M, Gogolin A, Weise M, Pfeifer J, Ziebart N, Heinemann U, von Kries JP, Nazaré M, Bader M. Specker E, et al. Among authors: heinemann u. J Med Chem. 2022 Aug 25;65(16):11126-11149. doi: 10.1021/acs.jmedchem.2c00598. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35921615
An Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils.
Ellson CD, Riça IG, Kim JS, Huang YM, Lim D, Mitra T, Hsu A, Wei EX, Barrett CD, Otterbein LE, Hauser CJ, Wahl M, Delbrück H, Heinemann U, Oschkinat H, Chang CA, Yaffe MB. Ellson CD, et al. Among authors: heinemann u. J Mol Biol. 2022 May 15;434(9):167533. doi: 10.1016/j.jmb.2022.167533. Epub 2022 Mar 18. J Mol Biol. 2022. PMID: 35314146
715 results