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Page 1
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data.
Saez-Atienzar S, Souza CDS, Chia R, Beal SN, Lorenzini I, Huang R, Levy J, Burciu C, Ding J, Gibbs JR, Jones A, Dewan R, Pensato V, Peverelli S, Corrado L, van Vugt JJFA, van Rheenen W, Tunca C, Bayraktar E, Xia M; International ALS Genomics Consortium; ITALSGEN Consortium; SLAGEN Consortium; Project MinE ALS Sequencing Consortium; Iacoangeli A, Shatunov A, Tiloca C, Ticozzi N, Verde F, Mazzini L, Kenna K, Al Khleifat A, Opie-Martin S, Raggi F, Filosto M, Piccinelli SC, Padovani A, Gagliardi S, Inghilleri M, Ferlini A, Vasta R, Calvo A, Moglia C, Canosa A, Manera U, Grassano M, Mandrioli J, Mora G, Lunetta C, Tanel R, Trojsi F, Cardinali P, Gallone S, Brunetti M, Galimberti D, Serpente M, Fenoglio C, Scarpini E, Comi GP, Corti S, Del Bo R, Ceroni M, Pinter GL, Taroni F, Bella ED, Bersano E, Curtis CJ, Lee SH, Chung R, Patel H, Morrison KE, Cooper-Knock J, Shaw PJ, Breen G, Dobson RJB, Dalgard CL; American Genome Center; Scholz SW, Al-Chalabi A, van den Berg LH, McLaughlin R, Hardiman O, Cereda C, Sorarù G, D'Alfonso S, Chandran S, Pal S, Ratti A, Gellera C, Johnson K, Doucet-O'Hare T, Pasternack N, Wang T, Nath A, Siciliano G, Silani V, Başak AN, Veldink JH, Camu W, Glass J… See abstract for full author list ➔ Saez-Atienzar S, et al. Among authors: doucet o hare t. Cell Genom. 2024 Nov 13;4(11):100679. doi: 10.1016/j.xgen.2024.100679. Epub 2024 Oct 21. Cell Genom. 2024. PMID: 39437787 Free article.
Endogenous retroviruses are dysregulated in ALS.
Pasternack N, Doucet-O'Hare T, Johnson K; NYGC Consortium; Paulsen O, Nath A. Pasternack N, et al. Among authors: doucet o hare t. iScience. 2024 May 28;27(7):110147. doi: 10.1016/j.isci.2024.110147. eCollection 2024 Jul 19. iScience. 2024. PMID: 38989463 Free PMC article.
TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression.
Garcia-Montojo M, Fathi S, Rastegar C, Simula ER, Doucet-O'Hare T, Cheng YHH, Abrams RPM, Pasternack N, Malik N, Bachani M, Disanza B, Maric D, Lee MH, Wang H, Santamaria U, Li W, Sampson K, Lorenzo JR, Sanchez IE, Mezghrani A, Li Y, Sechi LA, Pineda S, Heiman M, Kellis M, Steiner J, Nath A. Garcia-Montojo M, et al. Among authors: doucet o hare t. Nat Commun. 2024 May 16;15(1):4163. doi: 10.1038/s41467-024-48488-7. Nat Commun. 2024. PMID: 38755145 Free PMC article.
Antiretroviral Drug Repositioning for Glioblastoma.
Rivas SR, Mendez Valdez MJ, Chandar JS, Desgraves JF, Lu VM, Ampie L, Singh EB, Seetharam D, Ramsoomair CK, Hudson A, Ingle SM, Govindarajan V, Doucet-O'Hare TT, DeMarino C, Heiss JD, Nath A, Shah AH. Rivas SR, et al. Among authors: doucet o hare tt. Cancers (Basel). 2024 Apr 30;16(9):1754. doi: 10.3390/cancers16091754. Cancers (Basel). 2024. PMID: 38730705 Free PMC article.
Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma.
Shah AH, Rivas SR, Doucet-O'Hare TT, Govindarajan V, DeMarino C, Wang T, Ampie L, Zhang Y, Banasavadi-Siddegowda YK, Walbridge S, Maric D, Garcia-Montojo M, Suter RK, Lee MH, Zaghloul KA, Steiner J, Elkahloun AG, Chandar J, Seetharam D, Desgraves J, Li W, Johnson K, Ivan ME, Komotar RJ, Gilbert MR, Heiss JD, Nath A. Shah AH, et al. Among authors: doucet o hare tt. J Clin Invest. 2023 Jul 3;133(13):e167929. doi: 10.1172/JCI167929. J Clin Invest. 2023. PMID: 37395282 Free PMC article.
The Role of HERV-K in Cancer Stemness.
Rivas SR, Valdez MJM, Govindarajan V, Seetharam D, Doucet-O'Hare TT, Heiss JD, Shah AH. Rivas SR, et al. Among authors: doucet o hare tt. Viruses. 2022 Sep 12;14(9):2019. doi: 10.3390/v14092019. Viruses. 2022. PMID: 36146825 Free PMC article. Review.
Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic.
Steiner JP, Bachani M, Malik N, DeMarino C, Li W, Sampson K, Lee MH, Kowalak J, Bhaskar M, Doucet-O'Hare T, Garcia-Montojo M, Cowen M, Smith B, Reoma LB, Medina J, Brunel J, Pierquin J, Charvet B, Perron H, Nath A. Steiner JP, et al. Among authors: doucet o hare t. Ann Neurol. 2022 Oct;92(4):545-561. doi: 10.1002/ana.26452. Epub 2022 Jul 30. Ann Neurol. 2022. PMID: 35801347 Free PMC article.
20 results