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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications.
Schön J, Barut GT, Trüeb BS, Halwe NJ, Berenguer Veiga I, Kratzel A, Ulrich L, Kelly JN, Brügger M, Wylezich C, Taddeo A, Aguiar Moreira E, Túrós D, Grau-Roma L, Ahrens AK, Schlottau K, Britzke T, Breithaupt A, Corleis B, Kochmann J, Oliveira Esteves BI, Almeida L, Thomann L, Devisme C, Stalder H, Steiner S, Ochsenbein S, Schmied K, Labroussaa F, Jores J, V'kovski P, Cmiljanovic V, Alves MP, Benarafa C, Ebert N, Hoffmann D, Beer M, Thiel V. Schön J, et al. Among authors: brugger m. Nat Microbiol. 2024 Aug;9(8):2099-2112. doi: 10.1038/s41564-024-01755-1. Epub 2024 Jul 12. Nat Microbiol. 2024. PMID: 38997518 Free PMC article.
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.
Barut GT, Halwe NJ, Taddeo A, Kelly JN, Schön J, Ebert N, Ulrich L, Devisme C, Steiner S, Trüeb BS, Hoffmann B, Veiga IB, Leborgne NGF, Moreira EA, Breithaupt A, Wylezich C, Höper D, Wernike K, Godel A, Thomann L, Flück V, Stalder H, Brügger M, Esteves BIO, Zumkehr B, Beilleau G, Kratzel A, Schmied K, Ochsenbein S, Lang RM, Wider M, Machahua C, Dorn P, Marti TM, Funke-Chambour M, Rauch A, Widera M, Ciesek S, Dijkman R, Hoffmann D, Alves MP, Benarafa C, Beer M, Thiel V. Barut GT, et al. Among authors: brugger m. Nat Commun. 2022 Oct 7;13(1):5929. doi: 10.1038/s41467-022-33632-y. Nat Commun. 2022. PMID: 36207334 Free PMC article.
The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses.
Vielle NJ, García-Nicolás O, Oliveira Esteves BI, Brügger M, Summerfield A, Alves MP. Vielle NJ, et al. Among authors: brugger m. Front Microbiol. 2019 Apr 16;10:811. doi: 10.3389/fmicb.2019.00811. eCollection 2019. Front Microbiol. 2019. PMID: 31057517 Free PMC article.
SARS-CoV-2 can infect and propagate in human placenta explants.
Fahmi A, Brügger M, Démoulins T, Zumkehr B, Oliveira Esteves BI, Bracher L, Wotzkow C, Blank F, Thiel V, Baud D, Alves MP. Fahmi A, et al. Among authors: brugger m. Cell Rep Med. 2021 Dec 21;2(12):100456. doi: 10.1016/j.xcrm.2021.100456. Epub 2021 Nov 4. Cell Rep Med. 2021. PMID: 34751258 Free PMC article.
Generation of precision-cut slice cultures of human placenta.
Fahmi A, Brügger M, Zumkehr B, Oliveira Esteves BI, Baud D, Alves MP. Fahmi A, et al. Among authors: brugger m. STAR Protoc. 2022 Apr 12;3(2):101291. doi: 10.1016/j.xpro.2022.101291. eCollection 2022 Jun 17. STAR Protoc. 2022. PMID: 35463475 Free PMC article.
The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis.
Démoulins T, Brügger M, Zumkehr B, Oliveira Esteves BI, Mehinagic K, Fahmi A, Borcard L, Taddeo A, Jandrasits D, Posthaus H, Benarafa C, Ruggli N, Alves MP. Démoulins T, et al. Among authors: brugger m. PLoS Pathog. 2021 Apr 28;17(4):e1009529. doi: 10.1371/journal.ppat.1009529. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33909707 Free PMC article.
Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection.
Brügger M, Démoulins T, Barut GT, Zumkehr B, Oliveira Esteves BI, Mehinagic K, Haas Q, Schögler A, Rameix-Welti MA, Eléouët JF, Moehrlen U, Marti TM, Schmid RA, Summerfield A, Posthaus H, Ruggli N, Hall SRR, Alves MP. Brügger M, et al. PLoS Pathog. 2021 Jul 28;17(7):e1009789. doi: 10.1371/journal.ppat.1009789. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34320038 Free PMC article.
140 results