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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications.
Schön J, Barut GT, Trüeb BS, Halwe NJ, Berenguer Veiga I, Kratzel A, Ulrich L, Kelly JN, Brügger M, Wylezich C, Taddeo A, Aguiar Moreira E, Túrós D, Grau-Roma L, Ahrens AK, Schlottau K, Britzke T, Breithaupt A, Corleis B, Kochmann J, Oliveira Esteves BI, Almeida L, Thomann L, Devisme C, Stalder H, Steiner S, Ochsenbein S, Schmied K, Labroussaa F, Jores J, V'kovski P, Cmiljanovic V, Alves MP, Benarafa C, Ebert N, Hoffmann D, Beer M, Thiel V. Schön J, et al. Among authors: steiner s. Nat Microbiol. 2024 Aug;9(8):2099-2112. doi: 10.1038/s41564-024-01755-1. Epub 2024 Jul 12. Nat Microbiol. 2024. PMID: 38997518 Free PMC article.
Coronavirus biology and replication: implications for SARS-CoV-2.
V'kovski P, Kratzel A, Steiner S, Stalder H, Thiel V. V'kovski P, et al. Among authors: steiner s. Nat Rev Microbiol. 2021 Mar;19(3):155-170. doi: 10.1038/s41579-020-00468-6. Epub 2020 Oct 28. Nat Rev Microbiol. 2021. PMID: 33116300 Free PMC article. Review.
SARS-CoV-2 spike D614G change enhances replication and transmission.
Zhou B, Thao TTN, Hoffmann D, Taddeo A, Ebert N, Labroussaa F, Pohlmann A, King J, Steiner S, Kelly JN, Portmann J, Halwe NJ, Ulrich L, Trüeb BS, Fan X, Hoffmann B, Wang L, Thomann L, Lin X, Stalder H, Pozzi B, de Brot S, Jiang N, Cui D, Hossain J, Wilson MM, Keller MW, Stark TJ, Barnes JR, Dijkman R, Jores J, Benarafa C, Wentworth DE, Thiel V, Beer M. Zhou B, et al. Among authors: steiner s. Nature. 2021 Apr;592(7852):122-127. doi: 10.1038/s41586-021-03361-1. Epub 2021 Feb 26. Nature. 2021. PMID: 33636719
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.
Barut GT, Halwe NJ, Taddeo A, Kelly JN, Schön J, Ebert N, Ulrich L, Devisme C, Steiner S, Trüeb BS, Hoffmann B, Veiga IB, Leborgne NGF, Moreira EA, Breithaupt A, Wylezich C, Höper D, Wernike K, Godel A, Thomann L, Flück V, Stalder H, Brügger M, Esteves BIO, Zumkehr B, Beilleau G, Kratzel A, Schmied K, Ochsenbein S, Lang RM, Wider M, Machahua C, Dorn P, Marti TM, Funke-Chambour M, Rauch A, Widera M, Ciesek S, Dijkman R, Hoffmann D, Alves MP, Benarafa C, Beer M, Thiel V. Barut GT, et al. Among authors: steiner s. Nat Commun. 2022 Oct 7;13(1):5929. doi: 10.1038/s41467-022-33632-y. Nat Commun. 2022. PMID: 36207334 Free PMC article.
SARS-CoV-2 biology and host interactions.
Steiner S, Kratzel A, Barut GT, Lang RM, Aguiar Moreira E, Thomann L, Kelly JN, Thiel V. Steiner S, et al. Nat Rev Microbiol. 2024 Apr;22(4):206-225. doi: 10.1038/s41579-023-01003-z. Epub 2024 Jan 15. Nat Rev Microbiol. 2024. PMID: 38225365 Review.
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform.
Thi Nhu Thao T, Labroussaa F, Ebert N, V'kovski P, Stalder H, Portmann J, Kelly J, Steiner S, Holwerda M, Kratzel A, Gultom M, Schmied K, Laloli L, Hüsser L, Wider M, Pfaender S, Hirt D, Cippà V, Crespo-Pomar S, Schröder S, Muth D, Niemeyer D, Corman VM, Müller MA, Drosten C, Dijkman R, Jores J, Thiel V. Thi Nhu Thao T, et al. Among authors: steiner s. Nature. 2020 Jun;582(7813):561-565. doi: 10.1038/s41586-020-2294-9. Epub 2020 May 4. Nature. 2020. PMID: 32365353
SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility.
Zhou B, Thao TTN, Hoffmann D, Taddeo A, Ebert N, Labroussaa F, Pohlmann A, King J, Portmann J, Halwe NJ, Ulrich L, Trüeb BS, Kelly JN, Fan X, Hoffmann B, Steiner S, Wang L, Thomann L, Lin X, Stalder H, Pozzi B, de Brot S, Jiang N, Cui D, Hossain J, Wilson M, Keller M, Stark TJ, Barnes JR, Dijkman R, Jores J, Benarafa C, Wentworth DE, Thiel V, Beer M. Zhou B, et al. Among authors: steiner s. bioRxiv [Preprint]. 2020 Oct 27:2020.10.27.357558. doi: 10.1101/2020.10.27.357558. bioRxiv. 2020. Update in: Nature. 2021 Apr;592(7852):122-127. doi: 10.1038/s41586-021-03361-1. PMID: 33140052 Free PMC article. Updated. Preprint.
Temperature-dependent surface stability of SARS-CoV-2.
Kratzel A, Steiner S, Todt D, V'kovski P, Brueggemann Y, Steinmann J, Steinmann E, Thiel V, Pfaender S. Kratzel A, et al. Among authors: steiner s. J Infect. 2020 Sep;81(3):452-482. doi: 10.1016/j.jinf.2020.05.074. Epub 2020 Jun 3. J Infect. 2020. PMID: 32504748 Free PMC article. No abstract available.
Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium.
V'kovski P, Gultom M, Kelly JN, Steiner S, Russeil J, Mangeat B, Cora E, Pezoldt J, Holwerda M, Kratzel A, Laloli L, Wider M, Portmann J, Tran T, Ebert N, Stalder H, Hartmann R, Gardeux V, Alpern D, Deplancke B, Thiel V, Dijkman R. V'kovski P, et al. Among authors: steiner s. PLoS Biol. 2021 Mar 29;19(3):e3001158. doi: 10.1371/journal.pbio.3001158. eCollection 2021 Mar. PLoS Biol. 2021. PMID: 33780434 Free PMC article.
869 results