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Overcoming Chemoresistance in Cancer: The Promise of Crizotinib.
Musa S, Amara N, Selawi A, Wang J, Marchini C, Agbarya A, Mahajna J. Musa S, et al. Among authors: mahajna j. Cancers (Basel). 2024 Jul 7;16(13):2479. doi: 10.3390/cancers16132479. Cancers (Basel). 2024. PMID: 39001541 Free PMC article. Review.
Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K.
Mian AA, Haberbosch I, Khamaisie H, Agbarya A, Pietsch L, Eshel E, Najib D, Chiriches C, Ottmann OG, Hantschel O, Biondi RM, Ruthardt M, Mahajna J. Mian AA, et al. Among authors: mahajna j. Ann Hematol. 2021 Aug;100(8):2023-2029. doi: 10.1007/s00277-020-04357-z. Epub 2021 Jun 10. Ann Hematol. 2021. PMID: 34110462 Free PMC article.
48 results