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Correction: Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain.
Frey B, Holzinger D, Taylor K, Ehrnhoefer DE, Striebinger A, Biesinger S, Gasparini L, O'Neill MJ, Wegner F, Barghorn S, Höglinger GU, Heym RG. Frey B, et al. Among authors: ehrnhoefer de. Acta Neuropathol Commun. 2024 Jul 15;12(1):115. doi: 10.1186/s40478-024-01825-9. Acta Neuropathol Commun. 2024. PMID: 39004770 Free PMC article. No abstract available.
Author Correction: Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates.
Limorenko G, Tatli M, Kolla R, Nazarov S, Weil MT, Schöndorf DC, Geist D, Reinhardt P, Ehrnhoefer DE, Stahlberg H, Gasparini L, Lashuel HA. Limorenko G, et al. Among authors: ehrnhoefer de. Nat Commun. 2024 May 30;15(1):4595. doi: 10.1038/s41467-024-48976-w. Nat Commun. 2024. PMID: 38816466 Free PMC article. No abstract available.
Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain.
Frey B, Holzinger D, Taylor K, Ehrnhoefer DE, Striebinger A, Biesinger S, Gasparini L, O'Neill MJ, Wegner F, Barghorn S, Höglinger GU, Heym RG. Frey B, et al. Among authors: ehrnhoefer de. Acta Neuropathol Commun. 2023 Nov 14;11(1):181. doi: 10.1186/s40478-023-01676-w. Acta Neuropathol Commun. 2023. PMID: 37964332 Free PMC article.
Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation.
Reinhardt L, Musacchio F, Bichmann M, Behrendt A, Ercan-Herbst E, Stein J, Becher I, Haberkant P, Mader J, Schöndorf DC, Schmitt M, Korffmann J, Reinhardt P, Pohl C, Savitski M, Klein C, Gasparini L, Fuhrmann M, Ehrnhoefer DE. Reinhardt L, et al. Among authors: ehrnhoefer de. Neurobiol Dis. 2023 Jun 15;182:106126. doi: 10.1016/j.nbd.2023.106126. Epub 2023 Apr 20. Neurobiol Dis. 2023. PMID: 37086756 Free article.
Tau in the brain interstitial fluid is fragmented and seeding-competent.
Barini E, Plotzky G, Mordashova Y, Hoppe J, Rodriguez-Correa E, Julier S, LePrieult F, Mairhofer I, Mezler M, Biesinger S, Cik M, Meinhardt MW, Ercan-Herbst E, Ehrnhoefer DE, Striebinger A, Bodie K, Klein C, Gasparini L, Schlegel K. Barini E, et al. Among authors: ehrnhoefer de. Neurobiol Aging. 2022 Jan;109:64-77. doi: 10.1016/j.neurobiolaging.2021.09.013. Epub 2021 Sep 17. Neurobiol Aging. 2022. PMID: 34655982 Free article.
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE. Bichmann M, et al. Among authors: ehrnhoefer de. Mol Neurodegener. 2021 Jul 2;16(1):46. doi: 10.1186/s13024-021-00468-x. Mol Neurodegener. 2021. PMID: 34215303 Free PMC article.
Compromised IGF signaling causes caspase-6 activation in Huntington disease.
Skotte NH, Pouladi MA, Ehrnhoefer DE, Huynh K, Qiu X, Nielsen SMB, Nielsen TT, Nørremølle A, Hayden MR. Skotte NH, et al. Among authors: ehrnhoefer de. Exp Neurol. 2020 Oct;332:113396. doi: 10.1016/j.expneurol.2020.113396. Epub 2020 Jul 2. Exp Neurol. 2020. PMID: 32622701
A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain.
Ercan-Herbst E, Ehrig J, Schöndorf DC, Behrendt A, Klaus B, Gomez Ramos B, Prat Oriol N, Weber C, Ehrnhoefer DE. Ercan-Herbst E, et al. Among authors: ehrnhoefer de. Acta Neuropathol Commun. 2019 Dec 3;7(1):192. doi: 10.1186/s40478-019-0823-2. Acta Neuropathol Commun. 2019. PMID: 31796124 Free PMC article.
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR. Ehrnhoefer DE, et al. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. doi: 10.1016/j.chembiol.2019.07.001. Epub 2019 Jul 25. Cell Chem Biol. 2019. PMID: 31353319 Free PMC article.
40 results