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ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Vrijsen S, Besora-Casals L, van Veen S, Zielich J, Van den Haute C, Hamouda NN, Fischer C, Ghesquière B, Tournev I, Agostinis P, Baekelandt V, Eggermont J, Lambie E, Martin S, Vangheluwe P. Vrijsen S, et al. Among authors: vangheluwe p. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31198-31207. doi: 10.1073/pnas.1922342117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229544 Free PMC article.
A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Holemans T, Sørensen DM, van Veen S, Martin S, Hermans D, Kemmer GC, Van den Haute C, Baekelandt V, Günther Pomorski T, Agostinis P, Wuytack F, Palmgren M, Eggermont J, Vangheluwe P. Holemans T, et al. Among authors: vangheluwe p. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9040-5. doi: 10.1073/pnas.1508220112. Epub 2015 Jul 1. Proc Natl Acad Sci U S A. 2015. PMID: 26134396 Free PMC article.
P5B-ATPases in the mammalian polyamine transport system and their role in disease.
Azfar M, van Veen S, Houdou M, Hamouda NN, Eggermont J, Vangheluwe P. Azfar M, et al. Among authors: vangheluwe p. Biochim Biophys Acta Mol Cell Res. 2022 Dec;1869(12):119354. doi: 10.1016/j.bbamcr.2022.119354. Epub 2022 Sep 2. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 36064065 Free article. Review.
ATP13A2 deficiency disrupts lysosomal polyamine export.
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquière B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P. van Veen S, et al. Among authors: vangheluwe p. Nature. 2020 Feb;578(7795):419-424. doi: 10.1038/s41586-020-1968-7. Epub 2020 Jan 29. Nature. 2020. PMID: 31996848
85 results