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WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis.
Rodríguez Pérez F, Natwick D, Schiff L, McSwiggen D, Heckert A, Huey M, Morrison H, Loo M, Miranda RG, Filbin J, Ortega J, Van Buren K, Murnock D, Tao A, Butler R, Cheng K, Tarvestad W, Zhang Z, Gonzalez E, Miller RM, Kelly M, Tang Y, Ho J, Anderson D, Bashore C, Basham S. Rodríguez Pérez F, et al. Among authors: filbin j. Nat Commun. 2024 Jul 18;15(1):6059. doi: 10.1038/s41467-024-50178-3. Nat Commun. 2024. PMID: 39025847 Free PMC article.
Dynamic observations of CRISPR-Cas target recognition and cleavage heterogeneities.
Zhang Z, Jeong H, Zu D, Zhao X, Senaratne P, Filbin J, Silber B, Kang S, Gladstone A, Lau M, Cui G, Park Y, Lee SE. Zhang Z, et al. Among authors: filbin j. Nanophotonics. 2022 Aug 30;11(19):4419-4425. doi: 10.1515/nanoph-2022-0286. eCollection 2022 Sep. Nanophotonics. 2022. PMID: 39634158 Free PMC article.