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Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non-covalent BTK inhibitor, in healthy subjects: First-in-human phase I study.
Miyamoto K, Miller RM, Voors-Pette C, Oosterhaven JAF, van den Dobbelsteen M, Mihara K, Geldof M, Sato Y, Matsuda N, Kirita S, Sawa M, Arimura A. Miyamoto K, et al. Among authors: miller rm. Clin Transl Sci. 2024 Nov;17(11):e70060. doi: 10.1111/cts.70060. Clin Transl Sci. 2024. PMID: 39523516 Free PMC article. Clinical Trial.
Efficient synthesis for each of the eight stereoisomers of the iminosugars lentiginosine and 1,4-dideoxy-1,4-imino-D-arabinitol (DAB).
Liotta LJ, Antoine J, Brammer Basta LA, Campbell AS, Cole GY, Demick Brazile KA, Dogal Gardner NM, Fitzgerald ME, Francois JEK, French BM, Garafola SL, Giannetti CA, Granatosky EA, Harney AM, Hummel JT, Joyce AP, Keylor MH, Khubchandani JA, Korzeniecki C, Lieberman DC, Litterio JM, Maiorano MO, Marshall JF, McCarthy KA, Mendes Vieira A, Miller RM, Morrison ER, Moura SP, Neumann DF, Oliveira AF, Pace NJ, Plouffe JX, Pomfret MN, Reardon KN, Sheller-Miller SM, Smith MJ, Sullivan JL, Sweeney SW, Tougas KL. Liotta LJ, et al. Among authors: miller rm. Carbohydr Res. 2024 Nov;545:109280. doi: 10.1016/j.carres.2024.109280. Epub 2024 Sep 19. Carbohydr Res. 2024. PMID: 39326205
WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis.
Rodríguez Pérez F, Natwick D, Schiff L, McSwiggen D, Heckert A, Huey M, Morrison H, Loo M, Miranda RG, Filbin J, Ortega J, Van Buren K, Murnock D, Tao A, Butler R, Cheng K, Tarvestad W, Zhang Z, Gonzalez E, Miller RM, Kelly M, Tang Y, Ho J, Anderson D, Bashore C, Basham S. Rodríguez Pérez F, et al. Among authors: miller rm. Nat Commun. 2024 Jul 18;15(1):6059. doi: 10.1038/s41467-024-50178-3. Nat Commun. 2024. PMID: 39025847 Free PMC article.
A multi-taxon analysis of European Red Lists reveals major threats to biodiversity.
Hochkirch A, Bilz M, Ferreira CC, Danielczak A, Allen D, Nieto A, Rondinini C, Harding K, Hilton-Taylor C, Pollock CM, Seddon M, Vié JC, Alexander KNA, Beech E, Biscoito M, Braud Y, Burfield IJ, Buzzetti FM, Cálix M, Carpenter KE, Chao NL, Chobanov D, Christenhusz MJM, Collette BB, Comeros-Raynal MT, Cox N, Craig M, Cuttelod A, Darwall WRT, Dodelin B, Dulvy NK, Englefield E, Fay MF, Fettes N, Freyhof J, García S, Criado MG, Harvey M, Hodgetts N, Ieronymidou C, Kalkman VJ, Kell SP, Kemp J, Khela S, Lansdown RV, Lawson JM, Leaman DJ, Brehm JM, Maxted N, Miller RM, Neubert E, Odé B, Pollard D, Pollom R, Pople R, Presa Asensio JJ, Ralph GM, Rankou H, Rivers M, Roberts SPM, Russell B, Sennikov A, Soldati F, Staneva A, Stump E, Symes A, Telnov D, Temple H, Terry A, Timoshyna A, Swaay CV, Väre H, Walls RHL, Willemse L, Wilson B, Window J, Wright EGE, Zuna-Kratky T. Hochkirch A, et al. Among authors: miller rm. PLoS One. 2023 Nov 8;18(11):e0293083. doi: 10.1371/journal.pone.0293083. eCollection 2023. PLoS One. 2023. PMID: 37939028 Free PMC article.
Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation.
Tassone F, Protic D, Allen EG, Archibald AD, Baud A, Brown TW, Budimirovic DB, Cohen J, Dufour B, Eiges R, Elvassore N, Gabis LV, Grudzien SJ, Hall DA, Hessl D, Hogan A, Hunter JE, Jin P, Jiraanont P, Klusek J, Kooy RF, Kraan CM, Laterza C, Lee A, Lipworth K, Losh M, Loesch D, Lozano R, Mailick MR, Manolopoulos A, Martinez-Cerdeno V, McLennan Y, Miller RM, Montanaro FAM, Mosconi MW, Potter SN, Raspa M, Rivera SM, Shelly K, Todd PK, Tutak K, Wang JY, Wheeler A, Winarni TI, Zafarullah M, Hagerman RJ. Tassone F, et al. Among authors: miller rm. Cells. 2023 Sep 21;12(18):2330. doi: 10.3390/cells12182330. Cells. 2023. PMID: 37759552 Free PMC article. Review.
394 results