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Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice.
Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, Mordechai-Heyn T, Pitarresi JR, Atias D, Steinberg E, Bidany-Mizrahi T, Forkosh E, Katz LH, Benny O, Golan T, Hofree M, Stewart SA, Atlan KA, Zamir G, Stanger BZ, Berger M, Ben-Porath I. Assouline B, et al. Among authors: stewart sa. Nat Commun. 2024 Jul 22;15(1):6162. doi: 10.1038/s41467-024-50441-7. Nat Commun. 2024. PMID: 39039076 Free PMC article.
A framework for advancing our understanding of cancer-associated fibroblasts.
Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. Sahai E, et al. Nat Rev Cancer. 2020 Mar;20(3):174-186. doi: 10.1038/s41568-019-0238-1. Epub 2020 Jan 24. Nat Rev Cancer. 2020. PMID: 31980749 Free PMC article. Review.
Stress response regulates cancer fibroblasts.
Faget DV, Stewart SA. Faget DV, et al. Among authors: stewart sa. Nat Cell Biol. 2022 Jun;24(6):812-814. doi: 10.1038/s41556-022-00930-y. Nat Cell Biol. 2022. PMID: 35654838 No abstract available.
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression.
Ye J, Baer JM, Faget DV, Morikis VA, Ren Q, Melam A, Delgado AP, Luo X, Bagchi SM, Belle JI, Campos E, Friedman M, Veis DJ, Knudsen ES, Witkiewicz AK, Powers S, Longmore GD, DeNardo DG, Stewart SA. Ye J, et al. Among authors: stewart sa. Cancer Discov. 2024 Jul 1;14(7):1302-1323. doi: 10.1158/2159-8290.CD-23-0426. Cancer Discov. 2024. PMID: 38683161
Telomerase maintains telomere structure in normal human cells.
Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC. Masutomi K, et al. Among authors: stewart sa. Cell. 2003 Jul 25;114(2):241-53. doi: 10.1016/s0092-8674(03)00550-6. Cell. 2003. PMID: 12887925 Free article.
Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma.
Broestl L, Warrington NM, Grandison L, Abou-Antoun T, Tung O, Shenoy S, Tallman MM, Rhee G, Yang W, Sponagel J, Yang L, Kfoury-Beaumont N, Hill CM, Qanni SA, Mao DD, Kim AH, Stewart SA, Venere M, Luo J, Rubin JB. Broestl L, et al. Among authors: stewart sa. Commun Biol. 2022 Aug 2;5(1):781. doi: 10.1038/s42003-022-03743-9. Commun Biol. 2022. PMID: 35918603 Free PMC article.
207 results