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Page 1
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.
Dinkel L, Hummel S, Zenatti V, Malara M, Tillmann Y, Colombo A, Monasor LS, Suh JH, Logan T, Roth S, Paeger L, Hoffelner P, Bludau O, Schmidt A, Müller SA, Schifferer M, Nuscher B, Njavro JR, Prestel M, Bartos LM, Wind-Mark K, Slemann L, Hoermann L, Kunte ST, Gnörich J, Lindner S, Simons M, Herms J, Paquet D, Lichtenthaler SF, Bartenstein P, Franzmeier N, Liesz A, Grosche A, Bremova-Ertl T, Catarino C, Beblo S, Bergner C, Schneider SA, Strupp M, Di Paolo G, Brendel M, Tahirovic S. Dinkel L, et al. Among authors: gnorich j. Sci Transl Med. 2024 Dec 4;16(776):eadl4616. doi: 10.1126/scitranslmed.adl4616. Epub 2024 Dec 4. Sci Transl Med. 2024. PMID: 39630885
Aβ status assessment in a hypothetical scenario prior to treatment with disease-modifying therapies: Evidence from 10-year real-world experience at university memory clinics.
Brendel M, Parvizi T, Gnörich J, Topfstedt CE, Buerger K, Janowitz D, Rauchmann BS, Perneczky R, Kurz C, Mehrens D, Kunz WG, Kusche-Palenga J, Kling AB, Buchal A, Nestorova E, Silvaieh S, Wurm R, Traub-Weidinger T, Klotz S, Regelsberger G, Rominger A, Drzezga A, Levin J, Stögmann E, Franzmeier N, Höglinger GU. Brendel M, et al. Among authors: gnorich j. Alzheimers Dement (Amst). 2024 Nov 22;16(4):e70031. doi: 10.1002/dad2.70031. eCollection 2024 Oct-Dec. Alzheimers Dement (Amst). 2024. PMID: 39583651 Free PMC article.
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies.
Slemann L, Gnörich J, Hummel S, Bartos LM, Klaus C, Kling A, Kusche-Palenga J, Kunte ST, Kunze LH, Englert AL, Li Y, Vogler L, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Zwergal A, Hopfner F, Roemer-Cassiano SN, Biechele G, Stöcklein S, Bischof G, van Eimeren T, Drzezga A, Sabri O, Barthel H, Respondek G, Grimmer T, Levin J, Herms J, Paeger L, Willroider M, Beyer L, Höglinger GU, Roeber S, Franzmeier N, Brendel M. Slemann L, et al. Among authors: gnorich j. Acta Neuropathol. 2024 Nov 24;148(1):70. doi: 10.1007/s00401-024-02834-7. Acta Neuropathol. 2024. PMID: 39580770 Free PMC article.
Astroglial glucose uptake determines brain FDG-PET alterations and metabolic connectivity during healthy aging in mice.
Bartos LM, Kunte ST, Wagner S, Beumers P, Schaefer R, Zatcepin A, Li Y, Griessl M, Hoermann L, Wind-Mark K, Bartenstein P, Tahirovic S, Ziegler S, Brendel M, Gnörich J. Bartos LM, et al. Among authors: gnorich j. Neuroimage. 2024 Oct 15;300:120860. doi: 10.1016/j.neuroimage.2024.120860. Epub 2024 Sep 25. Neuroimage. 2024. PMID: 39332748 Free article.
Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies.
Dilcher R, Wall S, Groß M, Katzdobler S, Wagemann O, Palleis C, Weidinger E, Fietzek U, Bernhardt A, Kurz C, Ferschmann C, Scheifele M, Zaganjori M, Gnörich J, Bürger K, Janowitz D, Rauchmann BS, Stöcklein S, Bartenstein P, Villemagne V, Seibyl J, Sabri O, Barthel H, Perneczky R, Schöberl F, Zwergal A, Höglinger GU, Levin J, Franzmeier N, Brendel M. Dilcher R, et al. Among authors: gnorich j. Alzheimers Dement. 2024 Oct;20(10):6896-6909. doi: 10.1002/alz.14185. Epub 2024 Sep 12. Alzheimers Dement. 2024. PMID: 39263969 Free PMC article.
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, Brösamle D, Wendeln AC, Osei-Sarpong C, Heindl S, Liesz A, Stoecklein S, Biechele G, Finze A, Eckenweber F, Lindner S, Rominger A, Bartenstein P, Willem M, Tahirovic S, Herms J, Buerger K, Simons M, Haass C, Rupprecht R, Riemenschneider MJ, Albert NL, Beyer M, Neher JJ, Paeger L, Levin J, Höglinger GU, Perneczky R, Ziegler SI, Brendel M. Zatcepin A, et al. Among authors: gnorich j. Mol Neurodegener. 2024 Sep 5;19(1):64. doi: 10.1186/s13024-024-00752-6. Mol Neurodegener. 2024. PMID: 39238030 Free PMC article.
Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison.
Gnörich J, Koehler M, Wind-Mark K, Klaus C, Zatcepin A, Palumbo G, Lalia M, Monasor LS, Beyer L, Eckenweber F, Scheifele M, Gildehaus FJ, von Ungern-Sternberg B, Barthel H, Sabri O, Bartenstein P, Herms J, Tahirovic S, Franzmeier N, Ziegler S, Brendel M. Gnörich J, et al. Neuroimage. 2024 Aug 15;297:120748. doi: 10.1016/j.neuroimage.2024.120748. Epub 2024 Jul 26. Neuroimage. 2024. PMID: 39069223 Free article.
Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies.
Malpetti M, Roemer SN, Harris S, Gross M, Gnörich J, Stephens A, Dewenter A, Steward A, Biel D, Dehsarvi A, Wagner F, Müller A, Koglin N, Weidinger E, Palleis C, Katzdobler S, Rupprecht R, Perneczky R, Rauchmann BS, Levin J, Höglinger GU, Brendel M, Franzmeier N. Malpetti M, et al. Among authors: gnorich j. Mov Disord. 2024 Sep;39(9):1480-1492. doi: 10.1002/mds.29924. Epub 2024 Jul 18. Mov Disord. 2024. PMID: 39022835 Free article.
Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies.
Roemer SN, Brendel M, Gnörich J, Malpetti M, Zaganjori M, Quattrone A, Gross M, Steward A, Dewenter A, Wagner F, Dehsarvi A, Ferschmann C, Wall S, Palleis C, Rauchmann BS, Katzdobler S, Jäck A, Stockbauer A, Fietzek UM, Bernhardt AM, Weidinger E, Zwergal A, Stöcklein S, Perneczky R, Barthel H, Sabri O, Levin J, Höglinger GU, Franzmeier N. Roemer SN, et al. Among authors: gnorich j. Brain. 2024 Jul 5;147(7):2428-2439. doi: 10.1093/brain/awae174. Brain. 2024. PMID: 38842726
Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function.
Meindl M, Zatcepin A, Gnörich J, Scheifele M, Zaganjori M, Groß M, Lindner S, Schaefer R, Simmet M, Roemer S, Katzdobler S, Levin J, Höglinger G, Bischof AC, Barthel H, Sabri O, Bartenstein P, Saller T, Franzmeier N, Ziegler S, Brendel M. Meindl M, et al. Among authors: gnorich j. Eur J Nucl Med Mol Imaging. 2024 Sep;51(11):3252-3266. doi: 10.1007/s00259-024-06741-7. Epub 2024 May 8. Eur J Nucl Med Mol Imaging. 2024. PMID: 38717592 Free PMC article.
21 results