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Page 1
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging.
Occean JR, Yang N, Sun Y, Dawkins MS, Munk R, Belair C, Dar S, Anerillas C, Wang L, Shi C, Dunn C, Bernier M, Price NL, Kim JS, Cui CY, Fan J, Bhattacharyya M, De S, Maragkakis M, de Cabo R, Sidoli S, Sen P. Occean JR, et al. Among authors: de cabo r, de s. Nat Commun. 2024 Jul 28;15(1):6357. doi: 10.1038/s41467-024-50725-y. Nat Commun. 2024. PMID: 39069555 Free PMC article.
A BDNF-TrkB autocrine loop enhances senescent cell viability.
Anerillas C, Herman AB, Munk R, Garrido A, Lam KG, Payea MJ, Rossi M, Tsitsipatis D, Martindale JL, Piao Y, Mazan-Mamczarz K, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. Anerillas C, et al. Among authors: de cabo r, de s. Nat Commun. 2022 Oct 20;13(1):6228. doi: 10.1038/s41467-022-33709-8. Nat Commun. 2022. PMID: 36266274 Free PMC article.
A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. Among authors: de cabo r, de s. Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005. Epub 2023 Apr 27. Mol Cell. 2023. PMID: 37116496 Free PMC article.
Author Correction: A BDNF-TrkB autocrine loop enhances senescent cell viability.
Anerillas C, Herman AB, Munk R, Garrido A, Lam KG, Payea MJ, Rossi M, Tsitsipatis D, Martindale JL, Piao Y, Mazan-Mamczarz K, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. Anerillas C, et al. Among authors: de cabo r, de s. Nat Commun. 2022 Dec 7;13(1):7540. doi: 10.1038/s41467-022-35154-z. Nat Commun. 2022. PMID: 36477003 Free PMC article. No abstract available.
The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress.
Anerillas C, Mazan-Mamczarz K, Herman AB, Munk R, Lam KG, Calvo-Rubio M, Garrido A, Tsitsipatis D, Martindale JL, Altés G, Rossi M, Piao Y, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. Anerillas C, et al. Among authors: de cabo r, de s. Nat Aging. 2023 Oct;3(10):1237-1250. doi: 10.1038/s43587-023-00480-4. Epub 2023 Sep 4. Nat Aging. 2023. PMID: 37667102 Free PMC article.
Early SRC activation skews cell fate from apoptosis to senescence.
Anerillas C, Herman AB, Rossi M, Munk R, Lehrmann E, Martindale JL, Cui CY, Abdelmohsen K, De S, Gorospe M. Anerillas C, et al. Among authors: de s. Sci Adv. 2022 Apr 8;8(14):eabm0756. doi: 10.1126/sciadv.abm0756. Epub 2022 Apr 8. Sci Adv. 2022. PMID: 35394839 Free PMC article.
DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice.
Herman AB, Tsitsipatis D, Anerillas C, Mazan-Mamczarz K, Carr AE, Gregg JM, Wang M, Zhang J, Michel M, Henry-Smith CA, Harris SC, Munk R, Martindale JL, Piao Y, Fan J, Mattison JA, De S, Abdelmohsen K, Maul RW, Tanaka T, Moore AZ, DeMouth ME, Sidoli S, Ferrucci L, Liu Y, de Cabo R, Lakatta EG, Gorospe M. Herman AB, et al. Among authors: de cabo r, de s. J Clin Invest. 2023 Jun 15;133(12):e165933. doi: 10.1172/JCI165933. J Clin Invest. 2023. PMID: 37097759 Free PMC article.
Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.
Meng Q, Chen C, Yang N, Gololobova O, Shi C, Dunn CA, Rossi M, Martindale JL, Basisty N, Ding J, Delannoy M, Basu S, Mazan-Mamczarz K, Shin CH, Yang JH, Johnson PF, Witwer KW, Biragyn A, Sen P, Abdelmohsen K, De S, Gorospe M. Meng Q, et al. Among authors: de s. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2219801120. doi: 10.1073/pnas.2219801120. Epub 2023 Oct 20. Proc Natl Acad Sci U S A. 2023. PMID: 37862381 Free PMC article.
2,222 results