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Page 1
Endotypes of severe neutrophilic and eosinophilic asthma from multi-omics integration of U-BIOPRED sputum samples.
Kermani NZ, Li CX, Versi A, Badi Y, Sun K, Abdel-Aziz MI, Bonatti M, Maitland-van der Zee AH, Djukanovic R, Wheelock Å, Dahlen SE, Howarth P, Guo Y, Chung KF, Adcock IM; U‐BIOPRED Project Team. Kermani NZ, et al. Among authors: guo y. Clin Transl Med. 2024 Jul;14(7):e1771. doi: 10.1002/ctm2.1771. Clin Transl Med. 2024. PMID: 39073027 Free PMC article.
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.
Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, Chanez P, Dahlén B, Dahlen SE, Dyson K, Frey U, Geiser T, Gerhardsson de Verdier M, Gibeon D, Guo YK, Hashimoto S, Hedlin G, Jeyasingham E, Hekking PP, Higenbottam T, Horváth I, Knox AJ, Krug N, Erpenbeck VJ, Larsson LX, Lazarinis N, Matthews JG, Middelveld R, Montuschi P, Musial J, Myles D, Pahus L, Sandström T, Seibold W, Singer F, Strandberg K, Vestbo J, Vissing N, von Garnier C, Adcock IM, Wagers S, Rowe A, Howarth P, Wagener AH, Djukanovic R, Sterk PJ, Chung KF; U-BIOPRED Study Group. Shaw DE, et al. Eur Respir J. 2015 Nov;46(5):1308-21. doi: 10.1183/13993003.00779-2015. Epub 2015 Sep 10. Eur Respir J. 2015. PMID: 26357963 Free article.
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.
Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group. Lefaudeux D, et al. J Allergy Clin Immunol. 2017 Jun;139(6):1797-1807. doi: 10.1016/j.jaci.2016.08.048. Epub 2016 Oct 20. J Allergy Clin Immunol. 2017. PMID: 27773852 Free article.
Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.
Wilson SJ, Ward JA, Sousa AR, Corfield J, Bansal AT, De Meulder B, Lefaudeux D, Auffray C, Loza MJ, Baribaud F, Fitch N, Sterk PJ, Chung KF, Gibeon D, Sun K, Guo YK, Adcock I, Djukanovic R, Dahlen B, Chanez P, Shaw D, Krug N, Hohlfeld J, Sandström T, Howarth PH; U-BIOPRED Study Group. Wilson SJ, et al. Eur Respir J. 2016 Nov;48(5):1307-1319. doi: 10.1183/13993003.01129-2016. Epub 2016 Oct 6. Eur Respir J. 2016. PMID: 27799384 Free article.
Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.
Loza MJ, Djukanovic R, Chung KF, Horowitz D, Ma K, Branigan P, Barnathan ES, Susulic VS, Silkoff PE, Sterk PJ, Baribaud F; ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators. Loza MJ, et al. Respir Res. 2016 Dec 15;17(1):165. doi: 10.1186/s12931-016-0482-9. Respir Res. 2016. PMID: 27978840 Free PMC article.
A computational framework for complex disease stratification from multiple large-scale datasets.
De Meulder B, Lefaudeux D, Bansal AT, Mazein A, Chaiboonchoe A, Ahmed H, Balaur I, Saqi M, Pellet J, Ballereau S, Lemonnier N, Sun K, Pandis I, Yang X, Batuwitage M, Kretsos K, van Eyll J, Bedding A, Davison T, Dodson P, Larminie C, Postle A, Corfield J, Djukanovic R, Chung KF, Adcock IM, Guo YK, Sterk PJ, Manta A, Rowe A, Baribaud F, Auffray C; U-BIOPRED Study Group and the eTRIKS Consortium. De Meulder B, et al. BMC Syst Biol. 2018 May 29;12(1):60. doi: 10.1186/s12918-018-0556-z. BMC Syst Biol. 2018. PMID: 29843806 Free PMC article.
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma.
Ali MK, Kim RY, Brown AC, Mayall JR, Karim R, Pinkerton JW, Liu G, Martin KL, Starkey MR, Pillar AL, Donovan C, Pathinayake PS, Carroll OR, Trinder D, Tay HL, Badi YE, Kermani NZ, Guo YK, Aryal R, Mumby S, Pavlidis S, Adcock IM, Weaver J, Xenaki D, Oliver BG, Holliday EG, Foster PS, Wark PA, Johnstone DM, Milward EA, Hansbro PM, Horvat JC. Ali MK, et al. Among authors: guo yk. Eur Respir J. 2020 Apr 23;55(4):1901340. doi: 10.1183/13993003.01340-2019. Print 2020 Apr. Eur Respir J. 2020. PMID: 32184317 Free article.
Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics.
Zounemat Kermani N, Saqi M, Agapow P, Pavlidis S, Kuo C, Tan KS, Mumby S, Sun K, Loza M, Baribaud F, Sousa AR, Riley J, Wheelock AM, Wheelock CE, De Meulder B, Schofield J, Sánchez-Ovando S, Simpson JL, Baines KJ, Wark PA, Auffray C, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Guo YK, Chung KF; U-BIOPRED Project Team. Zounemat Kermani N, et al. Allergy. 2021 Jan;76(1):380-383. doi: 10.1111/all.14573. Epub 2020 Sep 16. Allergy. 2021. PMID: 32865817 No abstract available.
Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma.
Badi YE, Pavel AB, Pavlidis S, Riley JH, Bates S, Kermani NZ, Knowles R, Kolmert J, Wheelock CE, Worsley S, Uddin M, Alving K, Bakke PS, Behndig A, Caruso M, Chanez P, Fleming LJ, Fowler SJ, Frey U, Howarth P, Horváth I, Krug N, Maitland-van der Zee AH, Montuschi P, Roberts G, Sanak M, Shaw DE, Singer F, Sterk PJ, Djukanovic R, Dahlen SE, Guo YK, Chung KF, Guttman-Yassky E, Adcock IM; U-BIOPRED Study Group. Badi YE, et al. J Allergy Clin Immunol. 2022 Jan;149(1):89-101. doi: 10.1016/j.jaci.2021.04.010. Epub 2021 Apr 20. J Allergy Clin Immunol. 2022. PMID: 33891981 Free article. Clinical Trial.
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