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A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH.
Zhang Y, Wang X, Lin J, Liu J, Wang K, Nie Q, Ye C, Sun L, Ma Y, Qu R, Mao Y, Zhang X, Lu H, Xia P, Zhao D, Wang G, Zhang Z, Fu W, Jiang C, Pang Y. Zhang Y, et al. Among authors: wang x, wang g, wang k. Cell Metab. 2024 Aug 6;36(8):1823-1838.e6. doi: 10.1016/j.cmet.2024.07.004. Epub 2024 Jul 29. Cell Metab. 2024. PMID: 39079531
Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α.
Xia J, Chen H, Wang X, Chen W, Lin J, Xu F, Nie Q, Ye C, Zhong B, Zhao M, Yun C, Zeng G, Mao Y, Wen Y, Zhang X, Yan S, Wang X, Sun L, Liu F, Zhong C, Xia P, Jiang C, Rao H, Pang Y. Xia J, et al. Among authors: wang x. Nat Commun. 2024 Jun 4;15(1):4755. doi: 10.1038/s41467-024-48954-2. Nat Commun. 2024. PMID: 38834568 Free PMC article.
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C. Sun L, et al. Among authors: wang x, wang g. Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5. Nat Med. 2018. PMID: 30397356 Free PMC article.
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.
Zheng X, Chen T, Jiang R, Zhao A, Wu Q, Kuang J, Sun D, Ren Z, Li M, Zhao M, Wang S, Bao Y, Li H, Hu C, Dong B, Li D, Wu J, Xia J, Wang X, Lan K, Rajani C, Xie G, Lu A, Jia W, Jiang C, Jia W. Zheng X, et al. Among authors: wang x, wang s. Cell Metab. 2021 Apr 6;33(4):791-803.e7. doi: 10.1016/j.cmet.2020.11.017. Epub 2020 Dec 17. Cell Metab. 2021. PMID: 33338411 Free article.
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