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Loss of H3K9 trimethylation leads to premature aging.
Mrabti C, Yang N, Desdín-Micó G, Alonso-Calleja A, Vílchez-Acosta A, Pico S, Parras A, Piao Y, Schoenfeldt L, Luo S, Haghani A, Brooke R, Del Carmen Maza M, Branchina C, Maroun CY, von Meyenn F, Naveiras O, Horvath S, Sen P, Ocampo A. Mrabti C, et al. Among authors: branchina c. bioRxiv [Preprint]. 2024 Jul 24:2024.07.24.604929. doi: 10.1101/2024.07.24.604929. bioRxiv. 2024. PMID: 39091811 Free PMC article. Preprint.
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure.
Parras A, Vílchez-Acosta A, Desdín-Micó G, Picó S, Mrabti C, Montenegro-Borbolla E, Maroun CY, Haghani A, Brooke R, Del Carmen Maza M, Rechsteiner C, Battiston F, Branchina C, Perez K, Horvath S, Bertelli C, Sempoux C, Ocampo A. Parras A, et al. Among authors: branchina c. Nat Aging. 2023 Dec;3(12):1509-1520. doi: 10.1038/s43587-023-00528-5. Epub 2023 Nov 27. Nat Aging. 2023. PMID: 38012287