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187 results

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Page 1
Loss of H3K9 trimethylation leads to premature aging.
Mrabti C, Yang N, Desdín-Micó G, Alonso-Calleja A, Vílchez-Acosta A, Pico S, Parras A, Piao Y, Schoenfeldt L, Luo S, Haghani A, Brooke R, Del Carmen Maza M, Branchina C, Maroun CY, von Meyenn F, Naveiras O, Horvath S, Sen P, Ocampo A. Mrabti C, et al. Among authors: brooke r. bioRxiv [Preprint]. 2024 Jul 24:2024.07.24.604929. doi: 10.1101/2024.07.24.604929. bioRxiv. 2024. PMID: 39091811 Free PMC article. Preprint.
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure.
Parras A, Vílchez-Acosta A, Desdín-Micó G, Picó S, Mrabti C, Montenegro-Borbolla E, Maroun CY, Haghani A, Brooke R, Del Carmen Maza M, Rechsteiner C, Battiston F, Branchina C, Perez K, Horvath S, Bertelli C, Sempoux C, Ocampo A. Parras A, et al. Among authors: brooke r. Nat Aging. 2023 Dec;3(12):1509-1520. doi: 10.1038/s43587-023-00528-5. Epub 2023 Nov 27. Nat Aging. 2023. PMID: 38012287
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.
Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S. Jayne L, et al. Among authors: brooke rt. bioRxiv [Preprint]. 2024 Mar 25:2024.03.20.585828. doi: 10.1101/2024.03.20.585828. bioRxiv. 2024. PMID: 38585858 Free PMC article. Preprint.
Stress induced aging in mouse eye.
Xu Q, Rydz C, Nguyen Huu VA, Rocha L, Palomino La Torre C, Lee I, Cho W, Jabari M, Donello J, Lyon DC, Brooke RT, Horvath S, Weinreb RN, Ju WK, Foik A, Skowronska-Krawczyk D. Xu Q, et al. Aging Cell. 2022 Dec;21(12):e13737. doi: 10.1111/acel.13737. Epub 2022 Nov 17. Aging Cell. 2022. PMID: 36397653 Free PMC article.
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle.
Jones RG 3rd, Dimet-Wiley A, Haghani A, da Silva FM, Brightwell CR, Lim S, Khadgi S, Wen Y, Dungan CM, Brooke RT, Greene NP, Peterson CA, McCarthy JJ, Horvath S, Watowich SJ, Fry CS, Murach KA. Jones RG 3rd, et al. Among authors: brooke rt. J Physiol. 2023 Feb;601(4):763-782. doi: 10.1113/JP283836. Epub 2023 Jan 24. J Physiol. 2023. PMID: 36533424 Free PMC article.
Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction.
Horvath S, Singh K, Raj K, Khairnar S, Sanghavi A, Shrivastava A, Zoller JA, Li CZ, Herenu CB, Canatelli-Mallat M, Lehmann M, Habazin S, Novokmet M, Vučković F, Woods LCS, Martinez AG, Wang T, Chiavellini P, Levine AJ, Chen H, Brooke RT, Gordevicius J, Lauc G, Goya RG, Katcher HL. Horvath S, et al. bioRxiv [Preprint]. 2023 Aug 7:2023.08.06.552148. doi: 10.1101/2023.08.06.552148. bioRxiv. 2023. Update in: Geroscience. 2024 Feb;46(1):367-394. doi: 10.1007/s11357-023-00980-6 PMID: 37609328 Free PMC article. Updated. Preprint.
187 results